|
Model
|
Variables
|
Adjusted odds ratio (95% CI)
|
P valuea
|
|---|
|
I
|
Age
|
1.082 (1.026~1.141)
|
0.003**
|
|
Gender
|
0.859 (0.342~2.157)
|
0.746
|
|
Educational level
|
1.001 (0.901~1.112)
|
0.987
|
|
MMSE
|
0.768 (0.631~0.934)
|
0.008**
|
|
Statin therapy
|
0.191 (0.062~0.586)
|
0.004**
|
|
II
|
Age
|
1.062 (1.016~1.109)
|
0.008**
|
|
Gender
|
0.610 (0.277~1.345)
|
0.221
|
|
Educational level
|
1.094 (0.991~1.207)
|
0.074
|
|
MMSE
|
0.760 (0.643~0.900)
|
0.001**
|
|
Dyslipidemia
|
1.617 (0.718~3.644)
|
0.246
|
|
Statin therapy
|
0.279 (0.099~0.788)
|
0.016*
|
|
III
|
Age
|
1.072 (1.019~1.128)
|
0.007**
|
|
Gender
|
0.851 (0.322~2.247)
|
0.744
|
|
Educational level
|
1.034 (0.928~1.153)
|
0.543
|
|
MMSE
|
0.760 (0.625~0.924)
|
0.006**
|
|
Total cholesterol
|
0.942 (0.865~1.025)
|
0.167
|
|
LDL cholesterol
|
1.074 (0.985~1.171)
|
0.104
|
|
HDL cholesterol
|
1.060 (0.965~1.164)
|
0225
|
|
Triglyceride
|
1.010 (0.993~1.028)
|
0.252
|
|
Statin therapy
|
0.274 (0.096~0.274)
|
0.016*
|
|
IV
|
Age
|
1.064 (1.015~1.116)
|
0.010*
|
|
Gender
|
0.720 (0.303~1.712)
|
0.457
|
|
Educational level
|
1.070 (0.966~1.185)
|
0.194
|
|
MMSE
|
0.743 (0.618~0.894)
|
0.002**
|
|
Statin therapy
|
0.320 (0.123~ −0.836)
|
0.020*
|
|
LDL cholesterol
|
1.012 (1.000~1.025)
|
0.060
|
- Age, gender, educational level, and baseline MMSE were adjusted as covariates in all logistic regression models. Models were built by stepwise selection method with P value of entry = 0.1 and stay = 0.2. The tested independent variables in Model I were vascular risk factors (hypertension, diabetes mellitus, dyslipidemia, and smoking) and statin use. Models II and III were adjusted for history of dyslipidemia and lipid profile, separately, to test the association between statin use and conversion to dementia. Model IV was adjusted for statin use, to test the association between lipid profile (total cholesterol, LDL cholesterol, HDL cholesterol, and triglyceride) and conversion to AD at 24 months
- Abbreviations: APOE apolipoprotein E, HDL high-density lipoprotein, LDL low-density lipoprotein, MMSE Mini-Mental State Examination
- a* = P < 0.05, ** = P < 0.01
