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Table 3 Factors associated with conversion to dementia within 24 months

From: The contribution of vascular risk factors in neurodegenerative disorders: from mild cognitive impairment to Alzheimer’s disease

Model Variables Adjusted odds ratio (95% CI) P valuea
I Age 1.082 (1.026~1.141) 0.003**
Gender 0.859 (0.342~2.157) 0.746
Educational level 1.001 (0.901~1.112) 0.987
MMSE 0.768 (0.631~0.934) 0.008**
Statin therapy 0.191 (0.062~0.586) 0.004**
II Age 1.062 (1.016~1.109) 0.008**
Gender 0.610 (0.277~1.345) 0.221
Educational level 1.094 (0.991~1.207) 0.074
MMSE 0.760 (0.643~0.900) 0.001**
Dyslipidemia 1.617 (0.718~3.644) 0.246
Statin therapy 0.279 (0.099~0.788) 0.016*
III Age 1.072 (1.019~1.128) 0.007**
Gender 0.851 (0.322~2.247) 0.744
Educational level 1.034 (0.928~1.153) 0.543
MMSE 0.760 (0.625~0.924) 0.006**
Total cholesterol 0.942 (0.865~1.025) 0.167
LDL cholesterol 1.074 (0.985~1.171) 0.104
HDL cholesterol 1.060 (0.965~1.164) 0225
Triglyceride 1.010 (0.993~1.028) 0.252
Statin therapy 0.274 (0.096~0.274) 0.016*
IV Age 1.064 (1.015~1.116) 0.010*
Gender 0.720 (0.303~1.712) 0.457
Educational level 1.070 (0.966~1.185) 0.194
MMSE 0.743 (0.618~0.894) 0.002**
Statin therapy 0.320 (0.123~ −0.836) 0.020*
LDL cholesterol 1.012 (1.000~1.025) 0.060
  1. Age, gender, educational level, and baseline MMSE were adjusted as covariates in all logistic regression models. Models were built by stepwise selection method with P value of entry = 0.1 and stay = 0.2. The tested independent variables in Model I were vascular risk factors (hypertension, diabetes mellitus, dyslipidemia, and smoking) and statin use. Models II and III were adjusted for history of dyslipidemia and lipid profile, separately, to test the association between statin use and conversion to dementia. Model IV was adjusted for statin use, to test the association between lipid profile (total cholesterol, LDL cholesterol, HDL cholesterol, and triglyceride) and conversion to AD at 24 months
  2. Abbreviations: APOE apolipoprotein E, HDL high-density lipoprotein, LDL low-density lipoprotein, MMSE Mini-Mental State Examination
  3. a* = P < 0.05, ** = P < 0.01