The contribution of vascular risk factors in neurodegenerative disorders: from mild cognitive impairment to Alzheimer’s disease

Table 3 Factors associated with conversion to dementia within 24 months

Model	Variables	Adjusted odds ratio (95% CI)	P value^a
I	Age	1.082 (1.026~1.141)	0.003**
	Gender	0.859 (0.342~2.157)	0.746
	Educational level	1.001 (0.901~1.112)	0.987
	MMSE	0.768 (0.631~0.934)	0.008**
	Statin therapy	0.191 (0.062~0.586)	0.004**
II	Age	1.062 (1.016~1.109)	0.008**
	Gender	0.610 (0.277~1.345)	0.221
	Educational level	1.094 (0.991~1.207)	0.074
	MMSE	0.760 (0.643~0.900)	0.001**
	Dyslipidemia	1.617 (0.718~3.644)	0.246
	Statin therapy	0.279 (0.099~0.788)	0.016*
III	Age	1.072 (1.019~1.128)	0.007**
	Gender	0.851 (0.322~2.247)	0.744
	Educational level	1.034 (0.928~1.153)	0.543
	MMSE	0.760 (0.625~0.924)	0.006**
	Total cholesterol	0.942 (0.865~1.025)	0.167
	LDL cholesterol	1.074 (0.985~1.171)	0.104
	HDL cholesterol	1.060 (0.965~1.164)	0225
	Triglyceride	1.010 (0.993~1.028)	0.252
	Statin therapy	0.274 (0.096~0.274)	0.016*
IV	Age	1.064 (1.015~1.116)	0.010*
	Gender	0.720 (0.303~1.712)	0.457
	Educational level	1.070 (0.966~1.185)	0.194
	MMSE	0.743 (0.618~0.894)	0.002**
	Statin therapy	0.320 (0.123~ −0.836)	0.020*
	LDL cholesterol	1.012 (1.000~1.025)	0.060

Age, gender, educational level, and baseline MMSE were adjusted as covariates in all logistic regression models. Models were built by stepwise selection method with P value of entry = 0.1 and stay = 0.2. The tested independent variables in Model I were vascular risk factors (hypertension, diabetes mellitus, dyslipidemia, and smoking) and statin use. Models II and III were adjusted for history of dyslipidemia and lipid profile, separately, to test the association between statin use and conversion to dementia. Model IV was adjusted for statin use, to test the association between lipid profile (total cholesterol, LDL cholesterol, HDL cholesterol, and triglyceride) and conversion to AD at 24 months
Abbreviations: APOE apolipoprotein E, HDL high-density lipoprotein, LDL low-density lipoprotein, MMSE Mini-Mental State Examination
^a* = P < 0.05, ** = P < 0.01

ISSN: 1758-9193