Table 1 Demographics and biomarker profile of enrolled subjects
Enrolled subjects (N = 295) | |
|---|---|
Age, years | 72.7 ± 8.8 |
Gender, female % | 56% |
Educational level, years; median (IQR) | 12.0 (6.0–15.0) |
MMSE, median (IQR) | 27.0 (25.0–28.0) |
MCI type, % | |
Amnestic MCI | 83% |
Non-amnestic MCI | 17% |
APOE4 (carrying one or more ε4 allele) | 26% |
Reported vascular risk factors (no history/under Tx/no Tx)a, % | |
Hypertension, % | 43/52/4% |
Type 2 diabetes mellitus, % | 83/16/1% |
Dyslipidemia, % | 67/20/13% |
Smoking, (active smoker/quitted smoker), % | 8/8% |
Less than 1 pack per day | 11% |
1–2 packs per day | 4% |
More than 2 packs per day | 1% |
Serum lipid profile | |
Total cholesterol, mg/dL | 190.4 ± 38.0 |
LDL cholesterol, mg/dL | 112.1 ± 32.9 |
HDL cholesterol, mg/dL | 52.2 ± 14.7 |
Triglyceride, mg/dL | 122.0 ± 68.7 |
HbA1c | 6.09 ± 0.88 |
Fasting plasma glucose | 102.0 ± 24.0 |
Statin use (% in dyslipidemia) | 77 (41%) |
Current BMI, kg/m2 | 23.7 ± 4.3 |
Imaging biomarkers | |
Average Schelten’s score for MTA | 1.62 ± 0.72 |
Average Fazekas score for WMH | 0.90 ± 0.62 |
Entorhinal cortical thickness, mm | 3.102 ± 0.429 |
Hippocampal volume, mm3 | 3283 ± 588.3 |