Table 2 Subject demographics, CSF marker levels, and neuropsychological test scores by CSF profile
CSF profile | |||
|---|---|---|---|
Non-AD T-tau/Aβ42 ≤ 0.52 (n = 24) | AD T-tau/Aβ42 > 0.52 (n = 28) | p valuea | |
Demographics | |||
Gender (M/F) | 16/8 | 17/11 | 0.66 |
Age, years | 67 (46–80) | 70 (51–84) | 0.17 |
Education, years | 14.0 (9–20) | 12.5 (6–17) | 0.11 |
Clinical diagnosis | |||
SCI/MCI/AD/LBD | 10/13/0/1 | 2/9/16/1 | N/Ab |
CSF measures | |||
Aβ42 (pg/ml) | 703 (374–2332) | 454 (160–822) | N/Ac |
T-tau (pg/ml) | 173 (100–722) | 416 (132–838) | N/Ac |
NFL (ng/ml) | 1.9 (0.9–6.5) | 2.5 (1.2–4.5) | 0.15 |
YKL-40 (ng/ml) | 165 (83–399) | 203 (124–367) | 0.12 |
S100B (pg/ml) | 215 (132–335) | 230 (129–458) | 0.17 |
GFAP (ng/ml) | 1.0 (0.1–7.1) | 1.3 (0.5–21.3) | 0.09 |
Cognitive domains | |||
Global cognition | |||
MMSE, score | 28 (24–30) | 27 (24–30) | 0.01 |
Verbal episodic memory | |||
RAVLT immediate recall, score | 36 (23–66) | 26.5 (13–51) | 0.003 |
RAVLT delayed recall, score | 6.5 (0–15) | 1.5 (0–12) | < 0.001 |
RAVLT recognition-fp, score | 9.0 (3–15) | 5.5 (−3–15) | 0.003 |
Story immediate recall, score | 13.5 (5–17) | 8 (1–18) | 0.005 |
Story delayed recall, score | 12.0 (1–19) | 5.5 (0–16) | 0.002 |
Non-verbal episodic memory | |||
ROCF immediate recall, score | 13.3 (0–27) | 7.3 (0–26) | 0.04 |
ROCF delayed recall, score | 12.8 (0–25) | 8.5 (0–26) | 0.07 |
Language | |||
Verbal fluency animal, score | 20 (8–33) | 14 (4–27) | 0.02 |
Verbal fluency H+S, score | 24.0 (14–48) | 25.5 (6–63) | 1.00 |
Processing speed | |||
TMT-A, seconds | 43.5 (21–133) | 48.0 (27–116) | 0.22 |
Stroop—part I, seconds | 23.5 (20–42) | 24.5 (17–34) | 0.64 |
Executive functions | |||
TMT-B, seconds | 109 (44–340) | 153 (60–343) | 0.06 |
DSST, score | 8.5 (3–51) | 7.0 (2–61) | 0.24 |
Stroop 4th/3rd part, seconds | 2.1 (1.4–4.0) | 2.1 (1.6–5.8) | 0.25 |