Skip to main content
Fig. 5 | Alzheimer's Research & Therapy

Fig. 5

From: Intracranial alternating current stimulation facilitates neurogenesis in a mouse model of Alzheimer’s disease

Fig. 5

iACS increased the neurogenesis in the hippocampus of 5xFAD mouse brain. A–C Cells positive for Nestin and DCX were scarcer in the hippocampus of 5xFAD mouse brains than that of WT control brain. iACS increased both cells positive for Nestin or DCX in the hippocampus of 5xFAD mouse brains. Scale bar 100 μm (A–C) and 20 μm (A’–C’). D, E The numbers of cells positive for neural precursor cell marker (Nestin, D) or neurogenesis marker (DCX, E) were significantly reduced in the hippocampus of 5xFAD mouse brain and were significantly recovered following iACS. **P < 0.01 and ***P < 0.001. n = 5 mice for each group

Back to article page

Alzheimer's Research & Therapy

ISSN: 1758-9193