CSF total tau/α-synuclein ratio improved the diagnostic performance for Alzheimer’s disease as an indicator of tau phosphorylation

Table 2 Analysis of ROC curve for each biomarker between EOAD, LOAD versus PD, and HC

CSF biomarker	Cutoff	AUC	95% CI	Sensitivity (%)	Specificity (%)
Aβ₄₂	555.4^a	0.899	0.846–0.939	90	81
T-tau	318.9^a	0.908	0.857–0.946	81	91
P-tau₁₈₁	57.6^a	0.860	0.801–0.907	67	90
Aβ₄₂/P-tau₁₈₁	10.6	0.948	0.905–0.976	92	90
T-tau/α-syn	0.412	0.930	0.883–0.962	89	95
P-tau₁₈₁/α-syn	0.071	0.869	0.811–0.914	80	82
Aβ₄₂/P-tau₁₈₁, T-tau/α-syn	21.5	0.956	0.915–0.981	96	87

Abbreviation: ROC receiver operator characteristic, EOAD early-onset Alzheimer’s disease, LOAD late-onset Alzheimer’s disease, PD Parkinson’s disease, HC healthy control, CSF cerebrospinal fluid, AUC area under the curve, Aβ₄₂ amyloid-β 1-42, T-tau total tau, P-tau₁₈₁ phosphorylated tau 181, α-syn α-synuclein
^aUnit: pg/mL

ISSN: 1758-9193