EOAD | LOAD | MCI | SCD | PD | HC | P | |
---|---|---|---|---|---|---|---|
N | 71 | 34 | 11 | 17 | 45 | 32 | |
Sex (M/F) | 25/46 | 17/17 | 6/5 | 4/13 | 18/27 | 12/20 | .412b |
Agec | 58.0 (54.0–62.0) | 77.0 (73.0–80.0) | 68.0 (59.0–75.0) | 67.0 (61.0–73.0) | 68.0 (60.0–74.5) | 66.5 (62.0–68.0) | .000d |
MMSEe | 16.0 (13.0–20.0) | 19.0 (16.0–21.0) | 25.0 (24.0–26.0) | 29.0 (25.5–29.0) | – | 28.0 (27.0–30.0) | .000d |
CDR 0/0.5/1/2/3e | 0/20/33/15/3 | 0/13/15/6/0 | 0/10/1/0/0 | 2/15/0/0/0 | – | 15/17/0/0/0 | .000f |
CSF Aβ42 (pg/mL) | 326.8 (258.6–488.2) | 401.3 (239.6–587.3) | 737.5 (445.9–806.9) | 990.3 (904.3–1043.5) | 774.4 (595.2–967.2) | 1078.0 (982.4–1297.3) | .000d |
CSF T-tau (pg/mL) | 534.3 (386.2–732.9) | 442.6 (326.3–598.2) | 283.6 (203.7–490.8) | 321.9 (252.1–335.9) | 159.4 (116.9–215.8) | 203.3 (147.1–295.9) | .000d |
CSF P-tau181 (pg/mL) | 77.2 (53.9–106.0) | 69.9 (44.1–89.7) | 54.6 (40.1–83.3) | 51.5 (41.1–60.4) | 34.8 (25.5–43.6) | 40.3 (32.1–54.6) | .000d |
CSF α-syn (pg/mL) | 754.2 (526.7–1163.9) | 834.8 (586.5–1330.3) | 889.5 (628.7–1079.5) | 880.4 (689.5–1154.8) | 590.9 (420.0–842.3) | 669.8 (506.8–973.3) | .007d |
Amyloid-PET (+/−)g | 50/1 | 18/10 | 1/4 | 1/12 | – | 1/21 | .000b |