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Table 3 EOnonAD and LOnonAD demographic comparisons to CN. The comparisons were done using ANOVA and chi-square tests with two-sided p values. The Bonferroni-corrected pairwise differences relative to CN are discussed in the “Results” section. Significant p values (< 0.05) are bolded

From: Neurodegenerative changes in early- and late-onset cognitive impairment with and without brain amyloidosis

Variable CN (N = 291) EOnonADMCI (N = 113) EOnonADDEM (N = 8) p value LOnonADMCI (N = 151) LOnonADDEM(N = 24) p value
Age, years, mean (SD) 74.3 (6.4) 65.5 (5.8) 66.3 (5.8) < 0.001 77.6 (6.2) 79.4 (5.8) < 0.001
Sex, male % 52.2 50.4 50.0 0.944 59.6* 83.3* 0.008
Education, years, mean (SD) 16.7 (2.6) 16.2 (2.5) 15.6 (3.5) 0.095 16.3 (2.5) 15.6 (3.0) 0.037
%APOEε4, 0/1/2 alleles 77/22/1 68/30/2 71/14/14 0.028 86/13/2 83/13/4 0.173
Global CDR, mean (SD) 0.02 (0.09) 0.46 (0.17)*** 0.69 (0.26)*** < 0.001 0.48 (0.11)*** 0.83 (0.24)*** < 0.001
MMSE, mean (SD) 29.0 (1.3) 28.6 (1.5)*** 23.0 (2.4)*** < 0.001 28.4 (1.6)*** 23.6 (1.9)*** < 0.001
Global cortical [18F]-florbetapir SUVR, mean (SD) 1.03 (0.06) 1.03 (0.08) 1.04 (0.08) 0.214 1.01 (0.09) 1.01 (0.10) 0.160
Change in cortical [18F]-florbetapir SUVR referenced to CN (pvalue) ref − 0.0049 (0.1835)* − 0.0387 (0.0175)* N/A − 0.0099 (0.0091) 0.0093 (0.5425) N/A
Tau scans,N 126 38 3 N/A 51 2 N/A
  1. *MCI and DEM significantly different at p < 0.05
  2. ***MCI and DEM significantly different at p < 0.001
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Alzheimer's Research & Therapy

ISSN: 1758-9193