Table 2 EO vs. LO demographic comparisons. The comparisons were done using ANOVA and chi-square tests with two-sided p values. Significant p values (< 0.05) are bolded

Age, years, mean (SD)

65.4 (6.0)

76.4 (5.8)

< 0.001

65.5 (5.8)

77.6 (6.2)

< 0.001

Sex, male %

46.7

60.2

0.065

50.4

59.6

0.138

Education, years, mean (SD)

16.7 (2.8)

15.8 (2.8)

0.021

16.2 (2.5)

16.3 (2.5)

0.848

%APOE e4, 0/1/2 alleles

18/52/30

34/52/14

0.004

68/30/2

86/13/2

0.005

Global CDR, mean (SD)

0.50 (0.00)

0.50 (0.16)

0.823

0.46 (0.17)

0.48 (0.11)

0.167

MMSE, mean (SD)

27.8 (1.8)

27.4 (1.9)

0.229

28.6 (1.5)

28.4 (1.6)

0.175

Global cortical [¹⁸F]-florbetapir SUVR, mean (SD)

1.41 (0.15)

1.43 (0.17)

0.315

1.03 (0.08)

1.01 (0.09)

0.115

Tau scans,N

10

53

N/A

38

51

N/A

Diagnostic group (N)

EOAD_DEM(N = 50)

LOAD_DEM(N = 148)

pvalue

EOnonAD_DEM(N = 8)

LOnonAD_DEM(N = 24)

pvalue

Age, years, mean (SD)

64.7 (6.3)

78.3 (5.9)

< 0.001

66.3 (5.8)

79.4 (5.8)

< 0.001

Sex, male %

44.0

58.8

0.069

50.0

83.3

0.059

Education, years, mean (SD)

15.6 (2.4)

15.4 (3.0)

0.668

15.6 (3.5)

15.6 (3.0)

1.000

%APOE e4, 0/1/2 alleles

26/38/36

26/56/18

0.022

71/14/14

83/13/4

0.642

Global CDR, mean (SD)

0.87 (0.33)

0.84 (0.36)

0.579

0.69 (0.26)

0.83 (0.24)

0.155

MMSE, mean (SD)

22.5 (3.3)

23.0 (2.8)

0.283

23.0 (2.4)

23.6 (1.9)

0.453

Global cortical [¹⁸F]-florbetapir SUVR, mean (SD)

1.48 (0.13)

1.47 (0.16)

0.616

1.04 (0.08)

1.01 (0.10)

0.485

Tau scans,N

7

27

N/A

3

2

N/A