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Table 2 EO vs. LO demographic comparisons. The comparisons were done using ANOVA and chi-square tests with two-sided p values. Significant p values (< 0.05) are bolded

From: Neurodegenerative changes in early- and late-onset cognitive impairment with and without brain amyloidosis

Variable EOADMCI(N = 60) LOADMCI(N = 216) pvalue EOnonADMCI(N = 113) LOnonADMCI(N = 151) pvalue
Age, years, mean (SD) 65.4 (6.0) 76.4 (5.8) < 0.001 65.5 (5.8) 77.6 (6.2) < 0.001
Sex, male % 46.7 60.2 0.065 50.4 59.6 0.138
Education, years, mean (SD) 16.7 (2.8) 15.8 (2.8) 0.021 16.2 (2.5) 16.3 (2.5) 0.848
%APOE e4, 0/1/2 alleles 18/52/30 34/52/14 0.004 68/30/2 86/13/2 0.005
Global CDR, mean (SD) 0.50 (0.00) 0.50 (0.16) 0.823 0.46 (0.17) 0.48 (0.11) 0.167
MMSE, mean (SD) 27.8 (1.8) 27.4 (1.9) 0.229 28.6 (1.5) 28.4 (1.6) 0.175
Global cortical [18F]-florbetapir SUVR, mean (SD) 1.41 (0.15) 1.43 (0.17) 0.315 1.03 (0.08) 1.01 (0.09) 0.115
Tau scans,N 10 53 N/A 38 51 N/A
Diagnostic group (N) EOADDEM(N = 50) LOADDEM(N = 148) pvalue EOnonADDEM(N = 8) LOnonADDEM(N = 24) pvalue
Age, years, mean (SD) 64.7 (6.3) 78.3 (5.9) < 0.001 66.3 (5.8) 79.4 (5.8) < 0.001
Sex, male % 44.0 58.8 0.069 50.0 83.3 0.059
Education, years, mean (SD) 15.6 (2.4) 15.4 (3.0) 0.668 15.6 (3.5) 15.6 (3.0) 1.000
%APOE e4, 0/1/2 alleles 26/38/36 26/56/18 0.022 71/14/14 83/13/4 0.642
Global CDR, mean (SD) 0.87 (0.33) 0.84 (0.36) 0.579 0.69 (0.26) 0.83 (0.24) 0.155
MMSE, mean (SD) 22.5 (3.3) 23.0 (2.8) 0.283 23.0 (2.4) 23.6 (1.9) 0.453
Global cortical [18F]-florbetapir SUVR, mean (SD) 1.48 (0.13) 1.47 (0.16) 0.616 1.04 (0.08) 1.01 (0.10) 0.485
Tau scans,N 7 27 N/A 3 2 N/A