Table 1 EOAD and LOAD demographic comparisons to CN. The comparisons were done using ANOVA and chi-square tests with two-sided p values. The Bonferroni-corrected pairwise differences relative to CN are discussed in the “Results” section. Significant p values (< 0.05) are bolded

Age, years, mean (SD)

74.3 (6.4)

65.4 (6.0)

64.7 (6.3)

< 0.001

76.4 (5.8)**

78.3 (5.9)**

< 0.001

Sex, male %

52.2

46.7

44.0

0.461

60.2

58.8

0.174

Education, years, mean (SD)

16.7 (2.6)

16.7 (2.8)*

15.6 (2.4)*

0.022

15.8 (2.8)

15.4 (3.0)

< 0.001

%APOEε4, 0/1/2 alleles

77/22/1

18/52/30

26/38/36

< 0.001

34/52/14

26/56/18

< 0.001

Global CDR, mean (SD)

0.02 (0.09)

0.50 (0.00)***

0.87 (0.33)***

< 0.001

0.50 (0.16)***

0.84 (0.36)***

< 0.001

MMSE, mean (SD)

29.0 (1.3)

27.8 (1.8)***

22.5 (3.3)***

< 0.001

27.4 (1.9)***

23.0 (2.8)***

< 0.001

Global cortical [¹⁸F]-florbetapir SUVR, mean (SD)

1.03 (0.06)

1.41 (0.15)*

1.48 (0.13)*

< 0.001

1.43 (0.17)*

1.47 (0.16)*

< 0.001

Change in cortical [¹⁸F]-florbetapir SUVR referenced to CN (pvalue)

ref

0.0155 (0.0352)

0.0079 (0.5071)

N/A

0.0078 (0.1449)

0.0003 (0.9692)

N/A

Tau scans,N

126

10

7

N/A

53

27

N/A