Skip to main content

Table 1 EOAD and LOAD demographic comparisons to CN. The comparisons were done using ANOVA and chi-square tests with two-sided p values. The Bonferroni-corrected pairwise differences relative to CN are discussed in the “Results” section. Significant p values (< 0.05) are bolded

From: Neurodegenerative changes in early- and late-onset cognitive impairment with and without brain amyloidosis

Variable CN (N = 291) EOADMCI (N = 60) EOADDEM (N = 50) p value LOADMCI (N = 216) LOADDEM (N = 148) p value
Age, years, mean (SD) 74.3 (6.4) 65.4 (6.0) 64.7 (6.3) < 0.001 76.4 (5.8)** 78.3 (5.9)** < 0.001
Sex, male % 52.2 46.7 44.0 0.461 60.2 58.8 0.174
Education, years, mean (SD) 16.7 (2.6) 16.7 (2.8)* 15.6 (2.4)* 0.022 15.8 (2.8) 15.4 (3.0) < 0.001
%APOEε4, 0/1/2 alleles 77/22/1 18/52/30 26/38/36 < 0.001 34/52/14 26/56/18 < 0.001
Global CDR, mean (SD) 0.02 (0.09) 0.50 (0.00)*** 0.87 (0.33)*** < 0.001 0.50 (0.16)*** 0.84 (0.36)*** < 0.001
MMSE, mean (SD) 29.0 (1.3) 27.8 (1.8)*** 22.5 (3.3)*** < 0.001 27.4 (1.9)*** 23.0 (2.8)*** < 0.001
Global cortical [18F]-florbetapir SUVR, mean (SD) 1.03 (0.06) 1.41 (0.15)* 1.48 (0.13)* < 0.001 1.43 (0.17)* 1.47 (0.16)* < 0.001
Change in cortical [18F]-florbetapir SUVR referenced to CN (pvalue) ref 0.0155 (0.0352) 0.0079 (0.5071) N/A 0.0078 (0.1449) 0.0003 (0.9692) N/A
Tau scans,N 126 10 7 N/A 53 27 N/A
  1. *MCI and DEM significantly different at p < 0.05
  2. **MCI and DEM significantly different at p < 0.01
  3. ***MCI and DEM significantly different at p < 0.001