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Table 2 Proteins more abundant in AD relative to control patients, when both are first normalized to their respective soluble fraction. The ratio of AD to control is presented. A Welch’s t test was performed to assess statistical significance between the two groups

From: Diverse proteins aggregate in mild cognitive impairment and Alzheimer’s disease brain

Protein nameRatio AD/controlAdjusted P valueDescription
GSN3.29.71E−05Isoform 3 of gelsolin
FASN2.61.97E−05Fatty acid synthase
GPI2.20.0004Glucose-6-phosphate isomerase
CADPS2.10.0005Calcium-dependent secretion activator 1
UBA11.92.18E−05Ubiquitin-like modifier activating enzyme 1
PGAM1.93.97E−05Phosphoglycerate mutase 1
HSP90AB11.88.60E−05Heat shock protein HSP90-beta
ATIC1.81.95E−05Bifunctional purine biosynthesis protein PURH
HSP90AA11.80.0002Heat shock protein HSP90-alpha
CKB1.72.40E−05Creatine kinase B
OGDHL1.70.00052-oxoglutarate dehydrogenase-like, mitochondrial
HNRNPA2B11.70.0005Heterogeneous nuclear ribonucleoproteins A2/B1
VPS351.70.0003Vacuolar protein sorting-associated protein 35
RAP1GDS11.75.22E−06Rap1 GTPase-GDP dissociation stimulator 1
USP141.60.0026Ubiquitin carboxyl-terminal hydrolase 14