Table 2 Proteins more abundant in AD relative to control patients, when both are first normalized to their respective soluble fraction. The ratio of AD to control is presented. A Welch’s t test was performed to assess statistical significance between the two groups
From: Diverse proteins aggregate in mild cognitive impairment and Alzheimer’s disease brain
Protein name | Ratio AD/control | Adjusted P value | Description |
|---|---|---|---|
GSN | 3.2 | 9.71E−05 | Isoform 3 of gelsolin |
FASN | 2.6 | 1.97E−05 | Fatty acid synthase |
XRCC6 | 2.4 | 1.71E−06 | KU70 |
GPI | 2.2 | 0.0004 | Glucose-6-phosphate isomerase |
CADPS | 2.1 | 0.0005 | Calcium-dependent secretion activator 1 |
UBA1 | 1.9 | 2.18E−05 | Ubiquitin-like modifier activating enzyme 1 |
XRCC5 | 1.9 | 1.90E−06 | KU-80 |
PGAM | 1.9 | 3.97E−05 | Phosphoglycerate mutase 1 |
HSP90AB1 | 1.8 | 8.60E−05 | Heat shock protein HSP90-beta |
ATIC | 1.8 | 1.95E−05 | Bifunctional purine biosynthesis protein PURH |
HSP90AA1 | 1.8 | 0.0002 | Heat shock protein HSP90-alpha |
CKB | 1.7 | 2.40E−05 | Creatine kinase B |
OGDHL | 1.7 | 0.0005 | 2-oxoglutarate dehydrogenase-like, mitochondrial |
HNRNPA2B1 | 1.7 | 0.0005 | Heterogeneous nuclear ribonucleoproteins A2/B1 |
VPS35 | 1.7 | 0.0003 | Vacuolar protein sorting-associated protein 35 |
RAP1GDS1 | 1.7 | 5.22E−06 | Rap1 GTPase-GDP dissociation stimulator 1 |
CORO1A | 1.6 | 0.0005 | Coronin |
DBNL | 1.6 | 9.72E−05 | Drebrin |
USP14 | 1.6 | 0.0026 | Ubiquitin carboxyl-terminal hydrolase 14 |