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Fig. 5 | Alzheimer's Research & Therapy

Fig. 5

From: Young blood plasma reduces Alzheimer’s disease-like brain pathologies and ameliorates cognitive impairment in 3×Tg-AD mice

Fig. 5

Yong plasma decreases tau pathology in 3×Tg-AD mice. a, b Immunostaining with AT8 antibody. a Representative images with AT8-positive staining. b AT8-postive neurons in CA1 were counted from 8 sections (from every 6th serial brain sections) of each mouse. N = 11 for saline control. N = 10 for young plasma treatment. c, d Representative Western blots of the hippocampus developed with R134d against total tau, and several phosphorylation-dependent and site-specific tau antibodies. Densitometric quantification of blots after normalization with R134d is shown. Unpaired t test was used for b and d, *p < 0.05. N = 10 for young plasma, and n = 11 for vehicle (saline) control

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