TY - JOUR AU - Gong, C. X. AU - Liu, F. AU - Iqbal, K. PY - 2018 DA - 2018// TI - Multifactorial hypothesis and multi-targets for Alzheimer’s disease JO - J Alzheimers Dis VL - 64 UR - https://doi.org/10.3233/JAD-179921 DO - 10.3233/JAD-179921 ID - Gong2018 ER - TY - JOUR AU - Villeda, S. A. AU - Luo, J. AU - Mosher, K. I. AU - Zou, B. AU - Britschgi, M. AU - Bieri, G. PY - 2011 DA - 2011// TI - The ageing systemic milieu negatively regulates neurogenesis and cognitive function JO - Nature. VL - 477 UR - https://doi.org/10.1038/nature10357 DO - 10.1038/nature10357 ID - Villeda2011 ER - TY - JOUR AU - Katsimpardi, L. AU - Litterman, N. K. AU - Schein, P. A. AU - Miller, C. M. AU - Loffredo, F. S. AU - Wojtkiewicz, G. R. PY - 2014 DA - 2014// TI - Vascular and neurogenic rejuvenation of the aging mouse brain by young systemic factors JO - Science. VL - 344 UR - https://doi.org/10.1126/science.1251141 DO - 10.1126/science.1251141 ID - Katsimpardi2014 ER - TY - JOUR AU - Ruckh, J. M. AU - Zhao, J. W. AU - Shadrach, J. L. AU - Wijngaarden, P. AU - Rao, T. N. AU - Wagers, A. J. PY - 2012 DA - 2012// TI - Rejuvenation of regeneration in the aging central nervous system JO - Cell Stem Cell VL - 10 UR - https://doi.org/10.1016/j.stem.2011.11.019 DO - 10.1016/j.stem.2011.11.019 ID - Ruckh2012 ER - TY - JOUR AU - Villeda, S. A. AU - Plambeck, K. E. AU - Middeldorp, J. AU - Castellano, J. M. AU - Mosher, K. I. AU - Luo, J. PY - 2014 DA - 2014// TI - Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice JO - Nat Med VL - 20 UR - https://doi.org/10.1038/nm.3569 DO - 10.1038/nm.3569 ID - Villeda2014 ER - TY - JOUR AU - Conboy, I. M. AU - Conboy, M. J. AU - Wagers, A. J. AU - Girma, E. R. AU - Weissman, I. L. AU - Rando, T. A. PY - 2005 DA - 2005// TI - Rejuvenation of aged progenitor cells by exposure to a young systemic environment JO - Nature. VL - 433 UR - https://doi.org/10.1038/nature03260 DO - 10.1038/nature03260 ID - Conboy2005 ER - TY - JOUR AU - Castellano, J. M. AU - Mosher, K. I. AU - Abbey, R. J. AU - McBride, A. A. AU - James, M. L. AU - Berdnik, D. PY - 2017 DA - 2017// TI - Human umbilical cord plasma proteins revitalize hippocampal function in aged mice JO - Nature. VL - 544 UR - https://doi.org/10.1038/nature22067 DO - 10.1038/nature22067 ID - Castellano2017 ER - TY - JOUR AU - Horowitz, A. M. AU - Villeda, S. A. PY - 2017 DA - 2017// TI - Therapeutic potential of systemic brain rejuvenation strategies for neurodegenerative disease JO - F1000Res VL - 6 UR - https://doi.org/10.12688/f1000research.11437.1 DO - 10.12688/f1000research.11437.1 ID - Horowitz2017 ER - TY - JOUR AU - Khoury, R. AU - Ghossoub, E. PY - 2018 DA - 2018// TI - Young blood products: emerging treatment for Alzheimer’s disease? JO - Neural Regen Res VL - 13 UR - https://doi.org/10.4103/1673-5374.230277 DO - 10.4103/1673-5374.230277 ID - Khoury2018 ER - TY - JOUR AU - Dai, C. L. AU - Tung, Y. C. AU - Liu, F. AU - Gong, C. X. AU - Iqbal, K. PY - 2017 DA - 2017// TI - Tau passive immunization inhibits not only tau but also Abeta pathology JO - Alzheimers Res Ther VL - 9 UR - https://doi.org/10.1186/s13195-016-0227-5 DO - 10.1186/s13195-016-0227-5 ID - Dai2017 ER - TY - JOUR AU - Tatebayashi, Y. AU - Iqbal, K. AU - Grundke-Iqbal, I. PY - 1999 DA - 1999// TI - Dynamic regulation of expression and phosphorylation of tau by fibroblast growth factor-2 in neural progenitor cells from adult rat hippocampus JO - J Neurosci VL - 19 UR - https://doi.org/10.1523/JNEUROSCI.19-13-05245.1999 DO - 10.1523/JNEUROSCI.19-13-05245.1999 ID - Tatebayashi1999 ER - TY - JOUR AU - Greenberg, S. G. AU - Davies, P. AU - Schein, J. D. AU - Binder, L. I. PY - 1992 DA - 1992// TI - Hydrofluoric acid-treated tau PHF proteins display the same biochemical properties as normal tau JO - J Biol Chem VL - 267 ID - Greenberg1992 ER - TY - JOUR AU - Oddo, S. AU - Caccamo, A. AU - Shepherd, J. D. AU - Murphy, M. P. AU - Golde, T. E. AU - Kayed, R. PY - 2003 DA - 2003// TI - Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction JO - Neuron. VL - 39 UR - https://doi.org/10.1016/S0896-6273(03)00434-3 DO - 10.1016/S0896-6273(03)00434-3 ID - Oddo2003 ER - TY - JOUR AU - Oddo, S. AU - Caccamo, A. AU - Kitazawa, M. AU - Tseng, B. P. AU - LaFerla, F. M. PY - 2003 DA - 2003// TI - Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease JO - Neurobiol Aging VL - 24 UR - https://doi.org/10.1016/j.neurobiolaging.2003.08.012 DO - 10.1016/j.neurobiolaging.2003.08.012 ID - Oddo2003 ER - TY - JOUR AU - Dai, C. L. AU - Chen, X. AU - Kazim, S. F. AU - Liu, F. AU - Gong, C. X. AU - Grundke-Iqbal, I. PY - 2015 DA - 2015// TI - Passive immunization targeting the N-terminal projection domain of tau decreases tau pathology and improves cognition in a transgenic mouse model of Alzheimer disease and tauopathies JO - J Neural Transm (Vienna) VL - 122 UR - https://doi.org/10.1007/s00702-014-1315-y DO - 10.1007/s00702-014-1315-y ID - Dai2015 ER - TY - JOUR AU - Walsh, R. N. AU - Cummins, R. A. PY - 1976 DA - 1976// TI - The open-field test: a critical review JO - Psychol Bull VL - 83 UR - https://doi.org/10.1037/0033-2909.83.3.482 DO - 10.1037/0033-2909.83.3.482 ID - Walsh1976 ER - TY - JOUR AU - Chen, Y. AU - Liang, Z. AU - Tian, Z. AU - Blanchard, J. AU - Dai, C. L. AU - Chalbot, S. PY - 2014 DA - 2014// TI - Intracerebroventricular streptozotocin exacerbates Alzheimer-like changes of 3xTg-AD mice JO - Mol Neurobiol VL - 49 UR - https://doi.org/10.1007/s12035-013-8539-y DO - 10.1007/s12035-013-8539-y ID - Chen2014 ER - TY - JOUR AU - Morris, R. G. AU - Garrud, P. AU - Rawlins, J. N. AU - O'Keefe, J. PY - 1982 DA - 1982// TI - Place navigation impaired in rats with hippocampal lesions JO - Nature. VL - 297 UR - https://doi.org/10.1038/297681a0 DO - 10.1038/297681a0 ID - Morris1982 ER - TY - JOUR AU - D'Hooge, R. AU - Deyn, P. P. PY - 2001 DA - 2001// TI - Applications of the Morris water maze in the study of learning and memory. Brain research JO - Brain Res Rev VL - 36 UR - https://doi.org/10.1016/S0165-0173(01)00067-4 DO - 10.1016/S0165-0173(01)00067-4 ID - D'Hooge2001 ER - TY - JOUR AU - Vorhees, C. V. AU - Williams, M. T. PY - 2006 DA - 2006// TI - Morris water maze: procedures for assessing spatial and related forms of learning and memory JO - Nat Protoc VL - 1 UR - https://doi.org/10.1038/nprot.2006.116 DO - 10.1038/nprot.2006.116 ID - Vorhees2006 ER - TY - JOUR AU - Bevins, R. A. AU - Besheer, J. PY - 2006 DA - 2006// TI - Object recognition in rats and mice: a one-trial non-matching-to-sample learning task to study ‘recognition memory’ JO - Nat Protoc VL - 1 UR - https://doi.org/10.1038/nprot.2006.205 DO - 10.1038/nprot.2006.205 ID - Bevins2006 ER - TY - JOUR AU - Bussiere, T. AU - Bard, F. AU - Barbour, R. AU - Grajeda, H. AU - Guido, T. AU - Khan, K. PY - 2004 DA - 2004// TI - Morphological characterization of Thioflavin-S-positive amyloid plaques in transgenic Alzheimer mice and effect of passive Abeta immunotherapy on their clearance JO - Am J Pathol VL - 165 UR - https://doi.org/10.1016/S0002-9440(10)63360-3 DO - 10.1016/S0002-9440(10)63360-3 ID - Bussiere2004 ER - TY - JOUR AU - Gatta, V. AU - D'Aurora, M. AU - Granzotto, A. AU - Stuppia, L. AU - Sensi, S. L. PY - 2014 DA - 2014// TI - Early and sustained altered expression of aging-related genes in young 3xTg-AD mice JO - Cell Death Dis VL - 5 UR - https://doi.org/10.1038/cddis.2014.11 DO - 10.1038/cddis.2014.11 ID - Gatta2014 ER - TY - STD TI - Caruso D, Barron AM, Brown MA, Abbiati F, Carrero P, Pike CJ, et al. Age-related changes in neuroactive steroid levels in 3xTg-AD mice. Neurobiol Aging. 2013;34:1080–9. ID - ref24 ER - TY - JOUR AU - Xiang, Y. AU - Bu, X. L. AU - Liu, Y. H. AU - Zhu, C. AU - Shen, L. L. AU - Jiao, S. S. PY - 2015 DA - 2015// TI - Physiological amyloid-beta clearance in the periphery and its therapeutic potential for Alzheimer’s disease JO - Acta Neuropathol VL - 130 UR - https://doi.org/10.1007/s00401-015-1477-1 DO - 10.1007/s00401-015-1477-1 ID - Xiang2015 ER - TY - JOUR AU - Middeldorp, J. AU - Lehallier, B. AU - Villeda, S. A. AU - Miedema, S. S. AU - Evans, E. AU - Czirr, E. PY - 2016 DA - 2016// TI - Preclinical assessment of young blood plasma for Alzheimer disease JO - JAMA Neurol. VL - 73 UR - https://doi.org/10.1001/jamaneurol.2016.3185 DO - 10.1001/jamaneurol.2016.3185 ID - Middeldorp2016 ER - TY - JOUR AU - Sinha, M. AU - Jang, Y. C. AU - Oh, J. AU - Khong, D. AU - Wu, E. Y. AU - Manohar, R. PY - 2014 DA - 2014// TI - Restoring systemic GDF11 levels reverses age-related dysfunction in mouse skeletal muscle JO - Science. VL - 344 UR - https://doi.org/10.1126/science.1251152 DO - 10.1126/science.1251152 ID - Sinha2014 ER - TY - JOUR AU - Loffredo, F. S. AU - Steinhauser, M. L. AU - Jay, S. M. AU - Gannon, J. AU - Pancoast, J. R. AU - Yalamanchi, P. PY - 2013 DA - 2013// TI - Growth differentiation factor 11 is a circulating factor that reverses age-related cardiac hypertrophy JO - Cell. VL - 153 UR - https://doi.org/10.1016/j.cell.2013.04.015 DO - 10.1016/j.cell.2013.04.015 ID - Loffredo2013 ER - TY - JOUR AU - Wyss-Coray, T. PY - 2016 DA - 2016// TI - Ageing, neurodegeneration and brain rejuvenation JO - Nature. VL - 539 UR - https://doi.org/10.1038/nature20411 DO - 10.1038/nature20411 ID - Wyss-Coray2016 ER - TY - JOUR AU - Sha, S. J. AU - Deutsch, G. K. AU - Tian, L. AU - Richardson, K. AU - Coburn, M. AU - Gaudioso, J. L. PY - 2019 DA - 2019// TI - Safety, tolerability, and feasibility of young plasma infusion in the plasma for Alzheimer symptom amelioration study: a randomized clinical trial JO - JAMA Neurol. VL - 76 UR - https://doi.org/10.1001/jamaneurol.2018.3288 DO - 10.1001/jamaneurol.2018.3288 ID - Sha2019 ER - TY - JOUR AU - Ghiso, J. AU - Shayo, M. AU - Calero, M. AU - Ng, D. AU - Tomidokoro, Y. AU - Gandy, S. PY - 2014 DA - 2014// TI - Systemic catabolism of Alzheimer’s Abeta40 and Abeta42 JO - J Biol Chem VL - 279 UR - https://doi.org/10.1074/jbc.M407668200 DO - 10.1074/jbc.M407668200 ID - Ghiso2014 ER - TY - JOUR AU - Liu, A. AU - Guo, E. AU - Yang, J. AU - Yang, Y. AU - Liu, S. AU - Jiang, X. PY - 2018 DA - 2018// TI - Young plasma reverses age-dependent alterations in hepatic function through the restoration of autophagy JO - Aging Cell VL - 17 UR - https://doi.org/10.1111/acel.12708 DO - 10.1111/acel.12708 ID - Liu2018 ER - TY - JOUR AU - Nicholson, R. M. AU - Kusne, Y. AU - Nowak, L. A. AU - LaFerla, F. M. AU - Reiman, E. M. AU - Valla, J. PY - 2010 DA - 2010// TI - Regional cerebral glucose uptake in the 3xTG model of Alzheimer’s disease highlights common regional vulnerability across AD mouse models JO - Brain Res VL - 1347 UR - https://doi.org/10.1016/j.brainres.2010.05.084 DO - 10.1016/j.brainres.2010.05.084 ID - Nicholson2010 ER - TY - JOUR AU - Rodriguez, J. J. AU - Jones, V. C. AU - Tabuchi, M. AU - Allan, S. M. AU - Knight, E. M. AU - LaFerla, F. M. PY - 2008 DA - 2008// TI - Impaired adult neurogenesis in the dentate gyrus of a triple transgenic mouse model of Alzheimer’s disease JO - PLoS One VL - 3 UR - https://doi.org/10.1371/journal.pone.0002935 DO - 10.1371/journal.pone.0002935 ID - Rodriguez2008 ER - TY - JOUR AU - Janelsins, M. C. AU - Mastrangelo, M. A. AU - Oddo, S. AU - LaFerla, F. M. AU - Federoff, H. J. AU - Bowers, W. J. PY - 2005 DA - 2005// TI - Early correlation of microglial activation with enhanced tumor necrosis factor-alpha and monocyte chemoattractant protein-1 expression specifically within the entorhinal cortex of triple transgenic Alzheimer’s disease mice JO - J Neuroinflammation VL - 2 UR - https://doi.org/10.1186/1742-2094-2-23 DO - 10.1186/1742-2094-2-23 ID - Janelsins2005 ER - TY - JOUR AU - Dagher, N. N. AU - Najafi, A. R. AU - Kayala, K. M. AU - Elmore, M. R. AU - White, T. E. AU - Medeiros, R. PY - 2015 DA - 2015// TI - Colony-stimulating factor 1 receptor inhibition prevents microglial plaque association and improves cognition in 3xTg-AD mice JO - J Neuroinflammation VL - 12 UR - https://doi.org/10.1186/s12974-015-0366-9 DO - 10.1186/s12974-015-0366-9 ID - Dagher2015 ER - TY - JOUR AU - Tweedie, D. AU - Ferguson, R. A. AU - Fishman, K. AU - Frankola, K. A. AU - Praag, H. AU - Holloway, H. W. PY - 2012 DA - 2012// TI - Tumor necrosis factor-alpha synthesis inhibitor 3,6′-dithiothalidomide attenuates markers of inflammation, Alzheimer pathology and behavioral deficits in animal models of neuroinflammation and Alzheimer’s disease JO - J Neuroinflammation VL - 9 UR - https://doi.org/10.1186/1742-2094-9-106 DO - 10.1186/1742-2094-9-106 ID - Tweedie2012 ER - TY - JOUR AU - Choi, S. H. AU - Aid, S. AU - Caracciolo, L. AU - Minami, S. S. AU - Niikura, T. AU - Matsuoka, Y. PY - 2013 DA - 2013// TI - Cyclooxygenase-1 inhibition reduces amyloid pathology and improves memory deficits in a mouse model of Alzheimer’s disease JO - J Neurochem VL - 124 UR - https://doi.org/10.1111/jnc.12059 DO - 10.1111/jnc.12059 ID - Choi2013 ER - TY - JOUR AU - Baazaoui, N. AU - Iqbal, K. PY - 2017 DA - 2017// TI - Prevention of dendritic and synaptic deficits and cognitive impairment with a neurotrophic compound JO - Alzheimers Res Ther VL - 9 UR - https://doi.org/10.1186/s13195-017-0273-7 DO - 10.1186/s13195-017-0273-7 ID - Baazaoui2017 ER - TY - JOUR AU - Schafer, M. J. AU - LeBrasseur, N. K. PY - 2019 DA - 2019// TI - The influence of GDF11 on brain fate and function JO - Geroscience. VL - 41 UR - https://doi.org/10.1007/s11357-019-00054-6 DO - 10.1007/s11357-019-00054-6 ID - Schafer2019 ER - TY - JOUR AU - Baker, L. D. AU - Barsness, S. M. AU - Borson, S. AU - Merriam, G. R. AU - Friedman, S. D. AU - Craft, S. PY - 2012 DA - 2012// TI - Effects of growth hormone-releasing hormone on cognitive function in adults with mild cognitive impairment and healthy older adults: results of a controlled trial JO - Arch Neurol VL - 69 UR - https://doi.org/10.1001/archneurol.2012.1970 DO - 10.1001/archneurol.2012.1970 ID - Baker2012 ER - TY - JOUR AU - Friedman, S. D. AU - Baker, L. D. AU - Borson, S. AU - Jensen, J. E. AU - Barsness, S. M. AU - Craft, S. PY - 2013 DA - 2013// TI - Growth hormone-releasing hormone effects on brain gamma-aminobutyric acid levels in mild cognitive impairment and healthy aging JO - JAMA Neurol VL - 70 UR - https://doi.org/10.1001/jamaneurol.2013.1425 DO - 10.1001/jamaneurol.2013.1425 ID - Friedman2013 ER - TY - JOUR AU - Kazim, S. F. AU - Blanchard, J. AU - Dai, C. L. AU - Tung, Y. C. AU - LaFerla, F. M. AU - Iqbal, I. G. PY - 2014 DA - 2014// TI - Disease modifying effect of chronic oral treatment with a neurotrophic peptidergic compound in a triple transgenic mouse model of Alzheimer’s disease JO - Neurobiol Dis VL - 71 UR - https://doi.org/10.1016/j.nbd.2014.07.001 DO - 10.1016/j.nbd.2014.07.001 ID - Kazim2014 ER -