Fig. 3
From: The dynamics of biomarkers across the clinical spectrum of Alzheimer’s disease
Trajectories of cognitive, CSF, plasma and neuroimaging markers. The black solid line represents the best fit of the sigmoid function (linear for Aβ1–40, Aβ1–42 and t-tau in plasma), the dashed thick lines is the 95% prediction interval and the dashed thin lines are the estimated 95% bootstrap CI (the 2.5th and 97.5th percentiles for each time point). The light grey lines are the best fit of the function to 100 randomly selected bootstrap samples (out of the 500). The symbols show individual measurements (blue (circles), CN; orange (squares), MCI; red (asterisks), ADem). The vertical dashed and thick dotted lines represent the average expected time from ADem onset of individuals that are CN (27.75 years) and MCI (9.63 years) at baseline, respectively