Table 4 Baseline levels of plasma proteins implicated in iron and heme metabolism in CN individuals remaining stable and individuals showing progression to cognitive impairment (AIBL cohort)
Plasma proteins | Units | Stable | Progression | p value |
|---|---|---|---|---|
Ceruloplasmin | Mean (s.d.) | 0.001 (0.006) | 0.001 (0.014) | 0.867 |
Transferrin | Mean (s.d.) | 0.003 (0.008) | 0.007 (0.019) | 0.794 |
Haptoglobin | Mean (s.d.) | 0.005 (0.01) | 0.025 (0.024) | 0.458 |
Haptoglobin-related protein | Mean (s.d.) | 0.003 (0.011) | 0.036 (0.025) | 0.216 |
Hemopexin | Mean (s.d.) | 0.000 (0.010) | − 0.012 (0.022) | 0.844 |
Hemoglobin alpha 1 subunit | Mean (s.d.) | − 0.014 (0.016) | 0.042 (0.036) | 0.067 |
Hemoglobin beta subunit | Mean (s.d.) | − 0.024 (0.016) | 0.015 (0.037) | 0.263 |
Hemoglobin delta subunit | Mean (s.d.) | − 0.020 (0.016) | 0.024 (0.037) | 0.204 |
CD163 | Mean (s.d.) | 0.009 (0.015) | − 0.012 (0.035) | 0.465 |
LRP1 | Mean (s.d.) | 0.007 (0.026) | 0.028 (0.060) | 0.901 |