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Table 2 Baseline levels of plasma proteins involved in iron and heme metabolism in CN, MCI, and AD individuals

From: Plasma transferrin and hemopexin are associated with altered Aβ uptake and cognitive decline in Alzheimer’s disease pathology

Plasma proteins

 

CN

MCI

AD

p value

Ceruloplasmin

Mean (s.d.)

− 0.001 (0.004)

0.002 (0.013)

0.003 (0.012)

0.867

Transferrin

Mean (s.d.)

0.000 (0.006)

− 0.008 (0.019)

0.003 (0.0170

0.698

Haptoglobin

Mean (s.d.)

0.003 (0.007)

− 0.025 (0.025)

− 0.007 (0.023)

0.551

Haptoglobin-related protein

Mean (s.d.)

0.002 (0.008)

− 0.019 (0.027)

− 0.007 (0.024)

0.787

Hemopexin

Mean (s.d.)

− 0.003 (0.006)

− 0.016 (0.020)

0.037 (0.018)

0.059

Hemoglobin alpha 1 subunit

Mean (s.d.)

− 0.009 (0.012)

− 0.019 (0.039)

0.078 (0.036)

0.103

Hemoglobin beta subunit

Mean (s.d.)

− 0.017 (0.012)

0.019 (0.041)

0.116b (0.038)

0.001

Hemoglobin delta subunit

Mean (s.d.)

− 0.013 (0.012)

0.021 (0.040)

0.086b (0.037)

0.036

CD163

Mean (s.d.)

0.004 (0.01)

− 0.002 (0.034)

0.007 (0.031)

0.886

LRP1

Mean (s.d.)

0.008 (0.019)

− 0.077 (0.064)

− 0.008 (0.059)

0.424

  1. ANCOVA models adjusted for age, sex, and APOEε4 genotype. The mean and standard deviation (s.d.) are presented in the table with false discovery rate correction set at 5%
  2. Units of measurement = a.u
  3. aCN vs MCI
  4. bCN vs AD
  5. cMCI vs AD