The Alzheimer’s Prevention Initiative Composite Cognitive Test: a practical measure for tracking cognitive decline in preclinical Alzheimer’s disease

Table 5 Composite weights of the Alzheimer’s Prevention Initiative Preclinical Cognitive Composite (APCC)

Domain	Test item	Weight	Maximum possible	Weighted maximum
Perceptual Speed/Working Memory	Symbol Digit Modalities^‡	0.26	110	28.6
Orientation	MMSE Orientation to Time^‡	2.24	5	11.2
Orientation	MMSE Orientation to Place	2.14	5	10.7
Episodic Memory	Logical Memory Delayed^‡	0.53	25	13.2
Episodic Memory	Word List Memory Delayed	1.36	10	13.6
Visual Spatial	Judgment of Line Orientation	0.68	15	10.2
Visual Spatial	Raven’s Progressive Matrices (subset of 9 items from A and B)^‡	1.39	9	12.5*
	Total Score (sum of weighted maximums)			100

MMSE Mini-Mental State Examination
^‡Item included in original, late-onset AD composite cognitive test score (this composite consisted of Category Fluency [fruits and vegetables], Boston Naming Test [15 items], Logical Memory Delayed Recall, East Boston Naming Test Immediate Recall, Raven’s Progressive Matrices Subset, Symbol Digit Modalities and MMSE Orientation to Time [12])
*Rounded to the nearest 0.1

ISSN: 1758-9193