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Table 4 MSDRs for step-by-step iterations from the − 10 to 0 composite applied to different intervals

From: The Alzheimer’s Prevention Initiative Composite Cognitive Test: a practical measure for tracking cognitive decline in preclinical Alzheimer’s disease

Composite

− 10 to 0

− 11 to − 1

− 5 to − 1

Combination 1:

 Symbol Digit Modalities

 Digit Ordering

 MMSE Orientation to Time

 Logical Memory Delayed

 Word List Memory Delayed

 Judgment of Line Orientation

 Raven’s Progressive Matrices (subset of 9 items from A and B)

− 1.06

− 0.5331

− 0.4047

Combination 2:

 Symbol Digit Modalities

 Digit Ordering

 MMSE Orientation to Time

 MMSE Orientation to Place

 Logical Memory Delayed

 Word List Memory Delayed

 Judgment of Line Orientation

 Raven’s Progressive Matrices (subset of 9 items from A and B)

−1.09

− 0.5460

− 0.4172

Combination 3 (APCC):

 Symbol Digit Modalities

 MMSE Orientation to Time

 MMSE Orientation to Place

 Logical Memory Delayed

 Word List Memory Delayed

 Judgment of Line Orientation

 Raven’s Progressive Matrices (subset of 9 items from A and B)

− 1.10

− 0.5386

− 0.4124

  1. MMSE Mini-Mental State Examination, MSDR mean-to-standard deviation ratio