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Table 3 Three steps of PLS methodology

From: The Alzheimer’s Prevention Initiative Composite Cognitive Test: a practical measure for tracking cognitive decline in preclinical Alzheimer’s disease

 Cognitive domain
Perceptual speed/working memoryOrientationEpisodic memoryVisual spatial
Step 1: Original PLS Combination (Combination 1)1) Symbol Digit Modalities (Perceptual Speed)
2) Digit Ordering (Working Memory)
1) MMSE Orientation to Time1) Logical Memory Delayed
2) Word List Memory Delayed
1) Judgment of Line Orientation
2) Raven’s Progressive Matrices (subset of 9 items from A and B)
Step 2: Added MMSE Orientation to Place (Combination 2)1) Symbol Digit Modalities (Perceptual Speed)
2) Digit Ordering (Working Memory)
1) MMSE Orientation to Time
2) MMSE Orientation to Place
1) Logical Memory Delayed
2) Word List Memory Delayed
1) Judgment of Line Orientation
2) Raven’s Progressive Matrices (subset of 9 items from A and B)
Step 3: Removed Digit Ordering (Combination 3)1) Symbol Digit Modalities (Perceptual Speed)1) MMSE Orientation to Time
2) MMSE Orientation to Place
1) Logical Memory Delayed
2) Word List Memory Delayed
1) Judgment of Line Orientation
2) Raven’s Progressive Matrices (subset of 9 items from A and B)