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Table 5 Effect of exercise under exposure to the 40-Hz light flickering on apoptosis and cell death in the hippocampus

From: Physical exercise during exposure to 40-Hz light flicker improves cognitive functions in the 3xTg mouse model of Alzheimer’s disease

Group Bax Bcl-2 Cytochrome c Caspase-3 TUNEL (mm2)
CON 1.00 ± 0.14 1.00 ± 0.03 1.00 ± 0.05 1.00 ± 0.08 26.68 ± 2.63
AD 2.14 ± 0.11* 0.31 ± 0.05* 1.74 ± 0.07* 1.79 ± 0.08* 109.06 ± 5.92*
AD+40 1.60 ± 0.05*# 0.62 ± 0.05*# 1.42 ± 0.04*# 1.49 ± 0.04*# 59.59 ± 3.48*#
AD+EX 1.62 ± 0.07*# 0.68 ± 0.04*# 1.39 ± 0.04*# 1.41 ± 0.03*# 57.71 ± 4.34*#
AD+40+EX 0.99 ± 0.09*#+ 1.29 ± 0.09*#+ 0.90 ± 0.06*#+ 0.96 ± 0.02*#+ 32.99 ± 3.35*#+
  1. *P < .05 compared to the CON group, #P < .05 compared to the AD group, +P < .05 compared to the AD+40 and AD+EX