Physical exercise during exposure to 40-Hz light flicker improves cognitive functions in the 3xTg mouse model of Alzheimer’s disease

Table 5 Effect of exercise under exposure to the 40-Hz light flickering on apoptosis and cell death in the hippocampus

Group	Bax	Bcl-2	Cytochrome c	Caspase-3	TUNEL (mm²)
CON	1.00 ± 0.14	1.00 ± 0.03	1.00 ± 0.05	1.00 ± 0.08	26.68 ± 2.63
AD	2.14 ± 0.11*	0.31 ± 0.05*	1.74 ± 0.07*	1.79 ± 0.08*	109.06 ± 5.92*
AD+40	1.60 ± 0.05*^#	0.62 ± 0.05*^#	1.42 ± 0.04*^#	1.49 ± 0.04*^#	59.59 ± 3.48*^#
AD+EX	1.62 ± 0.07*^#	0.68 ± 0.04*^#	1.39 ± 0.04*^#	1.41 ± 0.03*^#	57.71 ± 4.34*^#
AD+40+EX	0.99 ± 0.09*^#+	1.29 ± 0.09*^#+	0.90 ± 0.06*^#+	0.96 ± 0.02*^#+	32.99 ± 3.35*^#+

*P < .05 compared to the CON group, ^#P < .05 compared to the AD group, ⁺P < .05 compared to the AD+40 and AD+EX

ISSN: 1758-9193