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Table 3 Parameter estimates of the final disease progression model

From: Testing whether the progression of Alzheimer’s disease changes with the year of publication, additional design, and geographical area: a modeling analysis of literature aggregate data

ParametersEstimates (RSE%)NONMEN 95% CIBootstrap medianBootstrap 95%PI
Fixed effect
α, points/week0.112 (6.5)0.098 ~ 0.1260.1140.102 ~ 0.139
β, points− 1.87 (26.4)− 2.84 ~ − 0.902− 2.03− 4.28 ~ − 1.27
 ET50, weeks7.99 (50.4)0.091 ~ 15.98.913.22 ~ 25.4
Covariate
θbaseline ADAS-cog score1.53 (34.8)0.487 ~ 2.571.460.581 ~ 2.96
θbaseline age− 2.17 (29.1)− 3.41 ~ − 0.931− 1.95− 3.73 ~ − 0.625
Random effect
η1 for α, %14.8 (43.0)2.33 ~ 27.315.52.9 ~ 27.3
η2 for β, %72.5 (15.2)50.9 ~ 94.174.453.3 ~ 106.6
 Pearson correlation− 0.717NA
Residual error
σaddition, points5.64 (6.8)4.89 ~ 6.395.544.83 ~ 6.26