Parameters | Estimates (RSE%) | NONMEN 95% CI | Bootstrap median | Bootstrap 95%PI |
---|---|---|---|---|
Fixed effect | ||||
α, points/week | 0.112 (6.5) | 0.098 ~ 0.126 | 0.114 | 0.102 ~ 0.139 |
β, points | − 1.87 (26.4) | − 2.84 ~ − 0.902 | − 2.03 | − 4.28 ~ − 1.27 |
ET50, weeks | 7.99 (50.4) | 0.091 ~ 15.9 | 8.91 | 3.22 ~ 25.4 |
Covariate | ||||
θbaseline ADAS-cog score | 1.53 (34.8) | 0.487 ~ 2.57 | 1.46 | 0.581 ~ 2.96 |
θbaseline age | − 2.17 (29.1) | − 3.41 ~ − 0.931 | − 1.95 | − 3.73 ~ − 0.625 |
Random effect | ||||
η1 for α, % | 14.8 (43.0) | 2.33 ~ 27.3 | 15.5 | 2.9 ~ 27.3 |
η2 for β, % | 72.5 (15.2) | 50.9 ~ 94.1 | 74.4 | 53.3 ~ 106.6 |
Pearson correlation | − 0.717 | NA | – | – |
Residual error | ||||
σaddition, points | 5.64 (6.8) | 4.89 ~ 6.39 | 5.54 | 4.83 ~ 6.26 |