Skip to main content

Table 3 Parameter estimates of the final disease progression model

From: Testing whether the progression of Alzheimer’s disease changes with the year of publication, additional design, and geographical area: a modeling analysis of literature aggregate data

Parameters

Estimates (RSE%)

NONMEN 95% CI

Bootstrap median

Bootstrap 95%PI

Fixed effect

α, points/week

0.112 (6.5)

0.098 ~ 0.126

0.114

0.102 ~ 0.139

β, points

− 1.87 (26.4)

− 2.84 ~ − 0.902

− 2.03

− 4.28 ~ − 1.27

 ET50, weeks

7.99 (50.4)

0.091 ~ 15.9

8.91

3.22 ~ 25.4

Covariate

θbaseline ADAS-cog score

1.53 (34.8)

0.487 ~ 2.57

1.46

0.581 ~ 2.96

θbaseline age

− 2.17 (29.1)

− 3.41 ~ − 0.931

− 1.95

− 3.73 ~ − 0.625

Random effect

η1 for α, %

14.8 (43.0)

2.33 ~ 27.3

15.5

2.9 ~ 27.3

η2 for β, %

72.5 (15.2)

50.9 ~ 94.1

74.4

53.3 ~ 106.6

 Pearson correlation

− 0.717

NA

Residual error

σaddition, points

5.64 (6.8)

4.89 ~ 6.39

5.54

4.83 ~ 6.26