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Table 2 Summary of pathways enriched in KEGG of proteins associated with aggregated amyloid according to APOE ε4 genotype

From: APOE ε4 genotype-dependent cerebrospinal fluid proteomic signatures in Alzheimer’s disease

Cognitive stage APOE ε4 carriers APOE ε4 non-carriers
Pathway enriched pFDR Proteins Pathway enriched pFDR Proteins
MMSE > 27 Complement and coagulation cascades 8.20E−12 C2, C3, C5, C6, CFB, CFH, F2, KNG1, PLG Cell adhesion molecules 0.000165 CADM3’, NRXN2, NRXN1, CNTN1, CNTNAP2
MMSE 27–24 No enrichment detected n.a. n.a. Complement and coagulation cascades 8.61E−13 C2, C3, C5, C6, CFB, F2, KNG1, PLG
MMSE < 24 Cell adhesion molecules 8.44E−09 CADM3’, CNTN1, CNTNAP2, NCAM1, NEGR1, NEO1, NRCAM, NRXN1, NRXN2, PVRL1’ No enrichment detected n.a. n.a.
  1. Please note that APOE and APP were excluded from enrichment analyses. Bold font indicates concordant difference compared to controls observed in EMIF-AD MBD; apostrophe (’) indicates not available in independent cohort
  2. n.a not applicable, MMSE Mini-Mental State Examination, FDR false discovery rate