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Table 1 Sample description

From: APOE ε4 genotype-dependent cerebrospinal fluid proteomic signatures in Alzheimer’s disease

Characteristic APOE ε4 non-carriers APOE ε4 carriers
Abeta normal (control), MMSE> 27 Abeta abnormal, MMSE > 27 Abeta abnormal, MMSE 27–24 Abeta abnormal, MMSE < 24 Abeta Normal, MMSE > 27 Abeta Abnormal, MMSE > 27 Abeta Abnormal, MMSE 27–24 Abeta Abnormal, MMSE < 24
N (% total sample) 60 (23%) 24 (9%) 34 (13%) 9 (3%) 8 (3%) 40 (15%) 63 (24%) 23 (27%)
E2/E3 15 (25%) 3 (12.5%) 6 (18%) 0 0 0 0 0
E3/E3 45 (75%) 21 (87.5%) 28 (82%) 9 (100%) 0 0 0 0
E2/E4 0 0 0 0 0 1 (2.5%) 2 (3%) 1 (4%)
E3/E4 0 0 0 0 8 (100%) 34 (85%) 41 (68%) 13 (57%)
E4/E4 0 0 0 0 0 5 (12.5%) 20 (33%) 9 (39%)
Age 75.30 (6.44) 76.70 (4.90) 75.37 (8.10) 78.82 (5.55) 72.1 (6.43) 74.97 (6.16) 74.53 (6.88) 73.32 (8.70)
Female, N (%) 29 (48%) 10 (42%) 13 (38%) 4 (44%) 4 (50%) 12 (30%) 30 (48%) 8 (35%)
Education years 16.00 (2.76) 16.08 (3.32) 15.62 (3.29) 16.22 (3.23) 15.50 (2.00) 16.02 (3.22) 15.25 (2.83) 15.30 (2.67)
MMSE 29.15 (0.73) 29.21 (0.78) 25.59 (1.05)c 21.89 (1.05)*** 29.12 (0.64) 28.73 (0.78)** 25.49 (1.11)*** 21.91 (1.12)***
Amyloid β 1–42 pg/ml 245.53 (26.38) 150.5 (28.76)*** 142.29 (25.06)*** 148.78 (19.32)*** 235.75 (22.13) 132.05 (23.19)*** 131.94 (28.07)*** 128.61 (23.52)***
T-tau pg/ml 63.41 (22.05) 88.12 (55.61)* 110.68 (51.83)*** 149.44 (75.91)*** 77.12 (19.77) 106.91 (48.96)*** 120.98 (54.37)*** 124.91 (51.75)***
P-tau pg/ml 20.56 (7.86) 31.33 (15.95)* 40.21 (18.04)*** 49.33 (20.43)*** 22 (4.41) 37.18 (14.81)*** 39.84 (13.70)*** 44.39 (23.78)***
APOE ε4 isoform 6.18 (2.18) 5.98 (3.26) 5.84 (2.68) 5.61 (4.44) 10.07 (5.80)c 11.92 (1.24)*** 11.89 (1.43)*** 11.63 (1.17)***
  1. Values are mean (SD). All comparisons are made against the control group (APOE ε4 non-carriers with normal amyloid and MMSE > 27). APOE ε4 isoform is the protein fragment that is specifically encoded by the ε4 allele, average log-intensity value are provided (all non-carriers have values below the level of detection, Spellman et al., 2015)
  2. *p < .05, **p < .01, ***p < .001