Table 1 Sample description
From: APOE ε4 genotype-dependent cerebrospinal fluid proteomic signatures in Alzheimer’s disease
Characteristic | APOE ε4 non-carriers | APOE ε4 carriers | ||||||
|---|---|---|---|---|---|---|---|---|
Abeta normal (control), MMSE> 27 | Abeta abnormal, MMSE > 27 | Abeta abnormal, MMSE 27–24 | Abeta abnormal, MMSE < 24 | Abeta Normal, MMSE > 27 | Abeta Abnormal, MMSE > 27 | Abeta Abnormal, MMSE 27–24 | Abeta Abnormal, MMSE < 24 | |
N (% total sample) | 60 (23%) | 24 (9%) | 34 (13%) | 9 (3%) | 8 (3%) | 40 (15%) | 63 (24%) | 23 (27%) |
E2/E3 | 15 (25%) | 3 (12.5%) | 6 (18%) | 0 | 0 | 0 | 0 | 0 |
E3/E3 | 45 (75%) | 21 (87.5%) | 28 (82%) | 9 (100%) | 0 | 0 | 0 | 0 |
E2/E4 | 0 | 0 | 0 | 0 | 0 | 1 (2.5%) | 2 (3%) | 1 (4%) |
E3/E4 | 0 | 0 | 0 | 0 | 8 (100%) | 34 (85%) | 41 (68%) | 13 (57%) |
E4/E4 | 0 | 0 | 0 | 0 | 0 | 5 (12.5%) | 20 (33%) | 9 (39%) |
Age | 75.30 (6.44) | 76.70 (4.90) | 75.37 (8.10) | 78.82 (5.55) | 72.1 (6.43) | 74.97 (6.16) | 74.53 (6.88) | 73.32 (8.70) |
Female, N (%) | 29 (48%) | 10 (42%) | 13 (38%) | 4 (44%) | 4 (50%) | 12 (30%) | 30 (48%) | 8 (35%) |
Education years | 16.00 (2.76) | 16.08 (3.32) | 15.62 (3.29) | 16.22 (3.23) | 15.50 (2.00) | 16.02 (3.22) | 15.25 (2.83) | 15.30 (2.67) |
MMSE | 29.15 (0.73) | 29.21 (0.78) | 25.59 (1.05)c | 21.89 (1.05)*** | 29.12 (0.64) | 28.73 (0.78)** | 25.49 (1.11)*** | 21.91 (1.12)*** |
Amyloid β 1–42 pg/ml | 245.53 (26.38) | 150.5 (28.76)*** | 142.29 (25.06)*** | 148.78 (19.32)*** | 235.75 (22.13) | 132.05 (23.19)*** | 131.94 (28.07)*** | 128.61 (23.52)*** |
T-tau pg/ml | 63.41 (22.05) | 88.12 (55.61)* | 110.68 (51.83)*** | 149.44 (75.91)*** | 77.12 (19.77) | 106.91 (48.96)*** | 120.98 (54.37)*** | 124.91 (51.75)*** |
P-tau pg/ml | 20.56 (7.86) | 31.33 (15.95)* | 40.21 (18.04)*** | 49.33 (20.43)*** | 22 (4.41) | 37.18 (14.81)*** | 39.84 (13.70)*** | 44.39 (23.78)*** |
APOE ε4 isoform | 6.18 (2.18) | 5.98 (3.26) | 5.84 (2.68) | 5.61 (4.44) | 10.07 (5.80)c | 11.92 (1.24)*** | 11.89 (1.43)*** | 11.63 (1.17)*** |