Table 3 Functional annotation analysis of predicted gene targets of identified candidate miRNAs
Candidate miRNA | Number of annotation clusters with enrichment score > 1.3 for predicted gene targets | Annotation cluster | Gene count* | Enrichment score | p value | FDR |
|---|---|---|---|---|---|---|
miR-146b-5p | 34 | Innate immune response | 24 | 13.8 | 6.1E−13 | 3.0E−10 |
Cellular response to cytokine stimulus | 33 | 11.72 | 1.9E−15 | 3.21E−12 | ||
Defence response to bacterium | 25 | 9.43 | 2.4E−12 | 4.03E−09 | ||
Interleukin-1 receptor binding | 7 | 6.35 | 3.66E−10 | 4.83E−07 | ||
Regulation of interleukin-6 production | 13 | 4 | 7.4E−11 | 1.26E−07 | ||
Regulation of interleukin-12 production | 7 | 3.87 | 3.89E−06 | 0.006623 | ||
Lipopolysaccharide-mediated signalling pathway | 8 | 3.82 | 1.50E−07 | 2.55E−04 | ||
Regulation of cytokine secretion | 10 | 3.68 | 4.44E−06 | 0.007556 | ||
miR-15b-5p | 31 | Apoptotic process | 91 | 6.08 | 2.2E−9 | 4.04E−06 |
Regulation of protein metabolic process | 119 | 5.71 | 9.9E−10 | 1.80E−06 | ||
Regulation of cell cycle | 36 | 2.55 | 3.2E−6 | 0.005875 |