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Table 2 Dysregulated miRNAs between amyloid-positive AD and amyloid-negative cognitively normal controls

From: Differential blood miRNA expression in brain amyloid imaging-defined Alzheimer’s disease and controls

MiRNA Log2 FC (AD vs controls) Fold changea p value (unadj) p value (FDR-corrected)
hsa-miR-218-1-5p 2.84 7.15 5.32E-08 4.34E-05
hsa-miR-4482-3p − 1.54 0.34 8.79E-05 0.035865
hsa-miR-16-2-3p 0.78 1.72 0.000409 0.095074
hsa-miR-4669-3p 1.30 2.45 0.000466 0.095074
hsa-let-7b-5p 0.75 1.69 0.000771 0.125787
hsa-miR-320a-3p 0.56 1.47 0.001074 0.132259
hsa-miR-574-5p 0.78 1.71 0.001135 0.132259
hsa-miR-5010-5p 0.72 1.65 0.001754 0.178899
hsa-miR-181a-1-5p 0.46 1.38 0.004002 0.277468
hsa-miR-1306-3p 0.68 1.60 0.004171 0.277468
hsa-miR-320c-1-3p 0.53 1.45 0.004248 0.277468
hsa-miR-3682-3p 0.68 1.60 0.004318 0.277468
hsa-miR-7113-5p 0.67 1.59 0.004566 0.277468
hsa-miR-30a-5p 0.67 1.59 0.00476 0.277468
hsa-miR-6793-3p 0.50 1.41 0.005823 0.316788
hsa-miR-3135a-5p 0.60 1.51 0.006553 0.328554
hsa-miR-548ae-2-5p 1.10 2.14 0.007103 0.328554
hsa-mir-3138 − 1.14 0.45 0.007248 0.328554
hsa-miR-6884-5p 0.58 1.49 0.008981 0.385731
hsa-miR-25-5p 0.44 1.36 0.010531 0.404056
hsa-miR-320b-1-3p 0.43 1.35 0.010797 0.404056
hsa-miR-4772-3p − 0.60 0.66 0.011461 0.404056
hsa-miR-3064-5p 0.56 1.47 0.011532 0.404056
hsa-mir-3607 − 0.53 0.69 0.012026 0.404056
hsa-miR-421-3p − 0.25 0.84 0.013088 0.404056
hsa-mir-3922 0.50 1.42 0.013536 0.404056
hsa-miR-3605-5p 0.46 1.37 0.014781 0.404056
hsa-miR-4649-3p − 0.53 0.69 0.01502 0.404056
hsa-miR-30a-3p 0.67 1.59 0.015235 0.404056
hsa-miR-542-3p 0.54 1.46 0.015267 0.404056
hsa-miR-4732-5p 0.42 1.34 0.01535 0.404056
hsa-miR-337-3p − 0.51 0.70 0.016418 0.412266
hsa-miR-320d-1-3p 0.47 1.38 0.017108 0.412266
hsa-mir-1273 g 0.36 1.29 0.017178 0.412266
hsa-miR-3913-1-3p − 0.34 0.79 0.018048 0.420787
hsa-miR-3691-3p − 0.35 0.78 0.020256 0.459135
hsa-miR-5701-1-5p − 0.57 0.67 0.023849 0.475508
hsa-miR-589-3p − 0.26 0.84 0.023928 0.475508
hsa-mir-202 − 0.62 0.65 0.02398 0.475508
hsa-miR-23b-5p 0.33 1.26 0.02412 0.475508
hsa-miR-3138-3p 0.46 1.38 0.024643 0.475508
hsa-miR-641-5p − 0.32 0.80 0.025083 0.475508
hsa-miR-15b-5p − 0.25 0.84 0.025333 0.475508
hsa-mir-1248 − 0.62 0.65 0.026133 0.475508
hsa-miR-664b-5p 0.43 1.34 0.026223 0.475508
hsa-miR-579-5p 0.33 1.26 0.027033 0.479535
hsa-miR-2277-3p 0.37 1.29 0.027747 0.481733
hsa-miR-1287-5p 0.47 1.38 0.031054 0.525366
hsa-miR-627-3p − 0.29 0.82 0.032362 0.525366
hsa-miR-423-5p 0.30 1.23 0.032829 0.525366
hsa-miR-92b-5p 0.41 1.33 0.032835 0.525366
hsa-miR-548n-3p − 0.40 0.76 0.035717 0.541575
hsa-miR-3607-3p − 0.51 0.70 0.035911 0.541575
hsa-miR-146b-5p − 0.29 0.82 0.036279 0.541575
hsa-miR-3667-5p 0.59 1.50 0.03678 0.541575
hsa-miR-185-3p 0.31 1.24 0.03858 0.541575
hsa-miR-10a-5p − 0.41 0.75 0.038723 0.541575
hsa-miR-628-5p − 0.30 0.81 0.039484 0.541575
hsa-miR-190a-5p 0.52 1.44 0.04009 0.541575
hsa-miR-1284-5p − 0.24 0.84 0.04149 0.541575
hsa-let-7a-3 0.50 1.41 0.042166 0.541575
hsa-miR-4742-3p − 0.32 0.80 0.04264 0.541575
hsa-miR-196a-1-5p 0.80 1.74 0.04283 0.541575
hsa-miR-6513-3p − 0.25 0.84 0.043181 0.541575
hsa-miR-1294-5p 0.39 1.31 0.043499 0.541575
hsa-miR-3130-1-5p − 0.27 0.83 0.043804 0.541575
hsa-miR-643-3p − 0.38 0.77 0.04469 0.544284
hsa-miR-6729-3p 0.40 1.32 0.045509 0.546106
hsa-mir-1229 0.48 1.40 0.046396 0.548684
hsa-miR-654-3p − 0.46 0.73 0.048297 0.563006
hsa-miR-128-1-3p − 0.23 0.85 0.049922 0.56594
  1. Log2FC log2 fold change, directionality denoted by + (upregulated) or – (downregulated) value when comparing AD to controls
  2. aMagnitude of fold change between AD compared to controls
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Alzheimer's Research & Therapy

ISSN: 1758-9193