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Table 1 Baseline demographic and clinical characteristics of the ADNI and NGF cohorts

From: The cholinergic system in subtypes of Alzheimer’s disease: an in vivo longitudinal MRI study

 ADNI cohortNGF cohortp value
HCAD patientsAD subtypesAD patientsADNI (4 AD subtypes and HC)ADNI (AD) and NGF (AD)
Typical ADLimbic-predominant ADHippocampal-sparing ADMinimal atrophy AD
Baseline, n69904618151110  
6 months, n6983411814104#  
12 months, n646831171376#  
24 months, n4354271395  
Sex, % female51%42%28%56%47%73%50%.035.641
Age75.3 (5.4)74.2 (7.7)75.6 (6.2)74.5 (6.9)75.8 (9.1)65.2 (7.4)*,†62.5 (5.7)< .001< .001
Years of education15.9 (2.7)15.2 (3.3)15.3 (3.8)15.1 (1.8)15.3 (3.4)14.6 (3.1)12.1 (4.0).761.007
CDR total, % (0.5/1)0/056/4450/5067/3360/4055/4550/50.671§.741
MMSE29 (1.1)23.4 (1.9)23.0 (1.8)23.8 (1.9)23.7 (1.9)24.2 (1.2)21.4 (2.4).126§.002
APOE, % ε4 carriers9%74%76%83%53%82%80%< .001.199
  1. The table shows count for number of participants at baseline, 6-, 12-, and 24-month follow-ups; mean and standard deviation (SD) for age, years of education, and MMSE; and percentage for sex, CDR total, and APOE ε4 carriers at baseline
  2. Abbreviations: n sample size, CDR clinical dementia rating, MMSE Mini-Mental State Examination, APOE apolipoprotein E, ε4 allele epsilon 4, AD Alzheimer’s disease, HC healthy controls, ADNI Alzheimer’s Disease Neuroimaging Initiative, NGF nerve growth factor
  3. *Significantly different to typical AD, limbic-predominant, and hippocampal-sparing
  4. Significantly different to healthy controls. Bold numbers indicate p values under 0.05
  5. Post hoc analysis showed no differences between the five ADNI groups
  6. §CDR and MMSE p values are reported for the comparison between the AD subtypes (excluding HC)
  7. #NGF patients with 6- and 12-month follow-up corresponded to different participants. Two of the NGF patients with 6 months follow-up were classified as typical AD subtype, one limbic-predominant, and one hippocampal-sparing subtype. Regarding the other six NGF patients with 12 months follow-up, four were classified as hippocampal-sparing and two as typical AD subtype