TY - JOUR AU - Masters, C. L. AU - Bateman, R. AU - Blennow, K. AU - Rowe, C. C. AU - Sperling, R. A. AU - Cummings, J. L. PY - 2015 DA - 2015// TI - Alzheimer’s disease JO - Nat Rev Dis Prim VL - 1 UR - https://doi.org/10.1038/nrdp.2015.56 DO - 10.1038/nrdp.2015.56 ID - Masters2015 ER - TY - JOUR AU - Ransohoff, R. M. PY - 2016 DA - 2016// TI - How neuroinflammation contributes to neurodegeneration JO - Science (80- ) VL - 353 ID - Ransohoff2016 ER - TY - JOUR AU - Sochocka, M. AU - Diniz, B. S. AU - Leszek, J. PY - 2017 DA - 2017// TI - Inflammatory response in the CNS: friend or foe? JO - Mol Neurobiol VL - 54 ID - Sochocka2017 ER - TY - JOUR AU - Winblad, B. AU - Amouyel, P. AU - Andrieu, S. PY - 2016 DA - 2016// TI - Defeating Alzheimer’s disease and other dementias: a priority for European science and society JO - Lancet Neurol VL - 15 ID - Winblad2016 ER - TY - JOUR AU - Kaiser, N. C. AU - Melrose, R. J. AU - Liu, C. PY - 2012 DA - 2012// TI - Neuropsychological and neuroimaging markers in early versus late-onset Alzheimer’s disease JO - Am J Alzheimer’s Dis Other Dementias®. VL - 27 ID - Kaiser2012 ER - TY - JOUR AU - Smits, L. L. AU - Pijnenburg, Y. A. L. AU - Koedam, E. L. G. E. PY - 2012 DA - 2012// TI - Early onset Alzheimer’s disease is associated with a distinct neuropsychological profile JO - J Alzheimers Dis VL - 30 ID - Smits2012 ER - TY - JOUR AU - Sá, F. AU - Pinto, P. AU - Cunha, C. PY - 2012 DA - 2012// TI - Differences between early and late-onset Alzheimer’s disease in neuropsychological tests JO - Front Neurol VL - 3 ID - Sá2012 ER - TY - JOUR AU - Panegyres, P. K. AU - Chen, H. -. Y. PY - 2013 DA - 2013// TI - Differences between early and late onset Alzheimer’s disease JO - Am J Neurodegener Dis VL - 2 ID - Panegyres2013 ER - TY - JOUR AU - Stanley, K. AU - Walker, Z. PY - 2014 DA - 2014// TI - Do patients with young onset Alzheimer’s disease deteriorate faster than those with late onset Alzheimer’s disease? A review of the literature JO - Int Psychogeriatrics VL - 26 ID - Stanley2014 ER - TY - JOUR AU - Wattmo, C. AU - Wallin, Å. K. PY - 2017 DA - 2017// TI - Early-versus late-onset Alzheimer’s disease in clinical practice: cognitive and global outcomes over 3 years JO - Alzheimers Res Ther VL - 9 ID - Wattmo2017 ER - TY - JOUR AU - Mendez, M. F. PY - 2019 DA - 2019// TI - Early-onset Alzheimer disease and its variants JO - Contin Lifelong Learn Neurol VL - 25 ID - Mendez2019 ER - TY - JOUR AU - Balasa, M. AU - Gelpi, E. AU - Antonell, A. PY - 2011 DA - 2011// TI - Clinical features and APOE genotype of pathologically proven early-onset Alzheimer disease JO - Neurology. VL - 76 ID - Balasa2011 ER - TY - JOUR AU - Bigio, E. H. AU - Hynan, L. S. AU - Sontag, E. AU - Satumtira, S. AU - White, C. L. PY - 2002 DA - 2002// TI - Synapse loss is greater in presenile than senile onset Alzheimer disease: implications for the cognitive reserve hypothesis JO - Neuropathol Appl Neurobiol VL - 28 ID - Bigio2002 ER - TY - JOUR AU - Palasí, A. AU - Gutiérrez-Iglesias, B. AU - Alegret, M. PY - 2015 DA - 2015// TI - Differentiated clinical presentation of early and late-onset Alzheimer’s disease: is 65 years of age providing a reliable threshold? JO - J Neurol VL - 262 ID - Palasí2015 ER - TY - JOUR AU - Frisoni, G. B. AU - Testa, C. AU - Sabattoli, F. AU - Beltramello, A. AU - Soininen, H. AU - Laakso, M. P. PY - 2005 DA - 2005// TI - Structural correlates of early and late onset Alzheimer’s disease: voxel based morphometric study JO - J Neurol Neurosurg Psychiatry VL - 76 ID - Frisoni2005 ER - TY - JOUR AU - Cerami, C. AU - Dodich, A. AU - Greco, L. PY - 2017 DA - 2017// TI - The role of single-subject brain metabolic patterns in the early differential diagnosis of primary progressive aphasias and in prediction of progression to dementia JO - J Alzheimers Dis VL - 55 ID - Cerami2017 ER - TY - JOUR AU - Perani, D. AU - Della Rosa, P. A. AU - Cerami, C. PY - 2014 DA - 2014// TI - Validation of an optimized SPM procedure for FDG-PET in dementia diagnosis in a clinical setting JO - NeuroImage Clin VL - 6 UR - https://doi.org/10.1016/j.nicl.2014.10.009 DO - 10.1016/j.nicl.2014.10.009 ID - Perani2014 ER - TY - JOUR AU - Vanhoutte, M. AU - Lopes, R. AU - Maureille, A. PY - 2016 DA - 2016// TI - Hypometabolism patterns using FDG-PET in typical and atypical sporadic forms of early-onset Alzheimer’s disease JO - Alzheimers Dement VL - 12 UR - https://doi.org/10.1016/j.jalz.2016.06.1041 DO - 10.1016/j.jalz.2016.06.1041 ID - Vanhoutte2016 ER - TY - JOUR AU - Caminiti, S. P. AU - Ballarini, T. AU - Sala, A. PY - 2018 DA - 2018// TI - FDG-PET and CSF biomarker accuracy in prediction of conversion to different dementias in a large multicentre MCI cohort JO - NeuroImage Clin. VL - 18 ID - Caminiti2018 ER - TY - JOUR AU - Iaccarino, L. AU - Chiotis, K. AU - Alongi, P. PY - 2017 DA - 2017// TI - A cross-validation of FDG-and amyloid-PET biomarkers in mild cognitive impairment for the risk prediction to dementia due to Alzheimer’s disease in a clinical setting JO - J Alzheimers Dis VL - 59 ID - Iaccarino2017 ER - TY - JOUR AU - Perani, D. AU - Cerami, C. AU - Caminiti, S. P. PY - 2016 DA - 2016// TI - Cross-validation of biomarkers for the early differential diagnosis and prognosis of dementia in a clinical setting JO - Eur J Nucl Med Mol Imaging VL - 43 ID - Perani2016 ER - TY - JOUR AU - Cerami, C. AU - Della Rosa, P. A. AU - Magnani, G. PY - 2015 DA - 2015// TI - Brain metabolic maps in mild cognitive impairment predict heterogeneity of progression to dementia JO - NeuroImage Clin. VL - 7 ID - Cerami2015 ER - TY - JOUR AU - Rabinovici, G. D. AU - Furst, A. J. AU - Alkalay, A. PY - 2010 DA - 2010// TI - Increased metabolic vulnerability in early-onset Alzheimer’s disease is not related to amyloid burden JO - Brain. VL - 133 ID - Rabinovici2010 ER - TY - JOUR AU - Chiaravalloti, A. AU - Koch, G. AU - Toniolo, S. PY - 2016 DA - 2016// TI - Comparison between early-onset and late-onset Alzheimer’s disease patients with amnestic presentation: CSF and 18F-FDG PET study JO - Dement Geriatr Cogn Dis Extra VL - 6 ID - Chiaravalloti2016 ER - TY - JOUR AU - Kim, E. J. AU - Cho, S. S. AU - Jeong, Y. PY - 2005 DA - 2005// TI - Glucose metabolism in early onset versus late onset Alzheimer’s disease: an SPM analysis of 120 patients JO - Brain. VL - 128 ID - Kim2005 ER - TY - JOUR AU - Vanhoutte, M. AU - Semah, F. AU - Sillaire, A. R. PY - 2017 DA - 2017// TI - 18F-FDG PET hypometabolism patterns reflect clinical heterogeneity in sporadic forms of early-onset Alzheimer’s disease JO - Neurobiol Aging VL - 59 ID - Vanhoutte2017 ER - TY - JOUR AU - Ballarini, T. AU - Iaccarino, L. AU - Magnani, G. PY - 2016 DA - 2016// TI - Neuropsychiatric subsyndromes and brain metabolic network dysfunctions in early onset Alzheimer’s disease JO - Hum Brain Mapp VL - 37 ID - Ballarini2016 ER - TY - JOUR AU - Sala, A. AU - Perani, D. PY - 2019 DA - 2019// TI - Brain molecular connectivity in neurodegenerative diseases: recent advances and new perspectives using positron emission tomography JO - Front Neurosci VL - 13 ID - Sala2019 ER - TY - JOUR AU - Passow, S. AU - Specht, K. AU - Adamsen, T. C. PY - 2015 DA - 2015// TI - Default-mode network functional connectivity is closely related to metabolic activity JO - Hum Brain Mapp VL - 36 ID - Passow2015 ER - TY - JOUR AU - Horwitz, B. AU - Duara, R. AU - Rapoport, S. I. PY - 1984 DA - 1984// TI - Intercorrelations of glucose metabolic rates between brain regions: application to healthy males in a state of reduced sensory input JO - J Cereb Blood Flow Metab VL - 4 ID - Horwitz1984 ER - TY - JOUR AU - Morbelli, S. AU - Drzezga, A. AU - Perneczky, R. PY - 2012 DA - 2012// TI - Resting metabolic connectivity in prodromal Alzheimer’s disease. A European Alzheimer Disease Consortium (EADC) project JO - Neurobiol Aging VL - 33 ID - Morbelli2012 ER - TY - JOUR AU - Malpetti, M. AU - Ballarini, T. AU - Presotto, L. PY - 2017 DA - 2017// TI - Gender differences in healthy aging and Alzheimer’s dementia: a 18F-FDG-PET study of brain and cognitive reserve JO - Hum Brain Mapp VL - 38 ID - Malpetti2017 ER - TY - JOUR AU - Chung, J. AU - Yoo, K. AU - Kim, E. AU - Na, D. L. AU - Jeong, Y. PY - 2016 DA - 2016// TI - Glucose metabolic brain networks in early-onset vs late-onset Alzheimer’s disease JO - Front Aging Neurosci VL - 8 ID - Chung2016 ER - TY - JOUR AU - Papadopoulos, V. AU - Baraldi, M. AU - Guilarte, T. R. PY - 2006 DA - 2006// TI - Translocator protein (18 kDa): new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function JO - Trends Pharmacol Sci VL - 27 ID - Papadopoulos2006 ER - TY - JOUR AU - Amor, S. AU - Puentes, F. AU - Baker, D. AU - Valk, P. PY - 2010 DA - 2010// TI - Inflammation in neurodegenerative diseases JO - Immunology. VL - 129 ID - Amor2010 ER - TY - JOUR AU - Cerami, C. AU - Iaccarino, L. AU - Perani, D. PY - 2017 DA - 2017// TI - Molecular imaging of neuroinflammation in neurodegenerative dementias: the role of in vivo PET imaging JO - Int J Mol Sci VL - 18 ID - Cerami2017 ER - TY - JOUR AU - Fan, Z. AU - Okello, A. A. AU - Brooks, D. J. AU - Edison, P. PY - 2015 DA - 2015// TI - Longitudinal influence of microglial activation and amyloid on neuronal function in Alzheimer’s disease JO - Brain. VL - 138 ID - Fan2015 ER - TY - JOUR AU - Fan, Z. AU - Aman, Y. AU - Ahmed, I. PY - 2015 DA - 2015// TI - Influence of microglial activation on neuronal function in Alzheimer’s and Parkinson’s disease dementia JO - Alzheimers Dement VL - 11 ID - Fan2015 ER - TY - JOUR AU - Kreisl, W. C. AU - Lyoo, C. H. AU - McGwier, M. PY - 2013 DA - 2013// TI - In vivo radioligand binding to translocator protein correlates with severity of Alzheimer’s disease JO - Brain. VL - 136 ID - Kreisl2013 ER - TY - JOUR AU - Kreisl, W. C. AU - Lyoo, C. H. AU - Liow, J. PY - 2016 DA - 2016// TI - 11C-PBR28 binding to translocator protein increases with progression of Alzheimer’s disease JO - Neurobiol Aging VL - 44 ID - Kreisl2016 ER - TY - JOUR AU - Matarrese, M. AU - Moresco, R. M. AU - Cappelli, A. PY - 2001 DA - 2001// TI - Labeling and evaluation of N-[11C] methylated quinoline-2-carboxamides as potential radioligands for visualization of peripheral benzodiazepine receptors JO - J Med Chem VL - 44 ID - Matarrese2001 ER - TY - JOUR AU - Della Rosa, P. A. AU - Cerami, C. AU - Gallivanone, F. PY - 2014 DA - 2014// TI - A standardized [18 F]-FDG-PET template for spatial normalization in statistical parametric mapping of dementia JO - Neuroinformatics. VL - 12 ID - Della Rosa2014 ER - TY - JOUR AU - Gunn, R. N. AU - Lammertsma, A. A. AU - Hume, S. P. AU - Cunningham, V. J. PY - 1997 DA - 1997// TI - Parametric imaging of ligand-receptor binding in PET using a simplified reference region model JO - Neuroimage. VL - 6 ID - Gunn1997 ER - TY - STD TI - Presotto L, Iaccarino L, Bettinardi V, Gianolli L, Perani D. An automated clustering algorithm for reference region extraction of brain 11 C-PK11195 studies. In: 2015 IEEE nuclear science symposium and medical imaging conference (NSS/MIC). IEEE; 2015:1–3. ID - ref44 ER - TY - JOUR AU - Turkheimer, F. E. AU - Edison, P. AU - Pavese, N. PY - 2007 DA - 2007// TI - Reference and target region modeling of [11C]-(R)-PK11195 brain studies JO - J Nucl Med VL - 48 ID - Turkheimer2007 ER - TY - STD TI - Passamonti L, Tsvetanov KA, Jones PS, et al. Neuroinflammation and functional connectivity in Alzheimer’s disease: interactive influences on cognitive performance. J Neurosci. 2019. doi: https://doi.org/10.1523/JNEUROSCI.2574-18.2019. ID - ref46 ER - TY - JOUR AU - Lee, D. S. AU - Kang, H. AU - Kim, H. PY - 2008 DA - 2008// TI - Metabolic connectivity by interregional correlation analysis using statistical parametric mapping (SPM) and FDG brain PET; methodological development and patterns of metabolic connectivity in adults JO - Eur J Nucl Med Mol Imaging VL - 35 ID - Lee2008 ER - TY - JOUR AU - McKhann, G. M. AU - Knopman, D. S. AU - Chertkow, H. PY - 2011 DA - 2011// TI - The diagnosis of dementia due to Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease JO - Alzheimers Dement VL - 7 ID - McKhann2011 ER - TY - JOUR AU - Dubois, B. AU - Feldman, H. H. AU - Jacova, C. PY - 2014 DA - 2014// TI - Advancing research diagnostic criteria for Alzheimer’s disease: the IWG-2 criteria JO - Lancet Neurol VL - 13 ID - Dubois2014 ER - TY - JOUR AU - Cagnin, A. AU - Brooks, D. J. AU - Kennedy, A. M. PY - 2001 DA - 2001// TI - In-vivo measurement of activated microglia in dementia JO - Lancet. VL - 358 ID - Cagnin2001 ER - TY - JOUR AU - Edison, P. AU - Archer, H. A. AU - Gerhard, A. PY - 2008 DA - 2008// TI - Microglia, amyloid, and cognition in Alzheimer’s disease: an [11C](R) PK11195-PET and [11C] PIB-PET study JO - Neurobiol Dis VL - 32 ID - Edison2008 ER - TY - JOUR AU - Yokokura, M. AU - Mori, N. AU - Yagi, S. PY - 2011 DA - 2011// TI - In vivo changes in microglial activation and amyloid deposits in brain regions with hypometabolism in Alzheimer’s disease JO - Eur J Nucl Med Mol Imaging VL - 38 ID - Yokokura2011 ER - TY - JOUR AU - Kreisl, W. C. AU - Lyoo, C. H. AU - Liow, J. -. S. PY - 2017 DA - 2017// TI - Distinct patterns of increased translocator protein in posterior cortical atrophy and amnestic Alzheimer’s disease JO - Neurobiol Aging VL - 51 ID - Kreisl2017 ER - TY - JOUR AU - Lee, C. Y. D. AU - Landreth, G. E. PY - 2010 DA - 2010// TI - The role of microglia in amyloid clearance from the AD brain JO - J Neural Transm VL - 117 ID - Lee2010 ER - TY - JOUR AU - Heneka, M. T. AU - Carson, M. J. AU - Khoury, J. PY - 2015 DA - 2015// TI - Neuroinflammation in Alzheimer’s disease JO - Lancet Neurol VL - 14 ID - Heneka2015 ER - TY - JOUR AU - Brelstaff, J. AU - Tolkovsky, A. M. AU - Ghetti, B. AU - Goedert, M. AU - Spillantini, M. G. PY - 2018 DA - 2018// TI - Living neurons with tau filaments aberrantly expose phosphatidylserine and are phagocytosed by microglia JO - Cell Rep VL - 24 ID - Brelstaff2018 ER -