Skip to main content

Table 2 Cox regression analysis for the association between subjective cognitive decline and subsequent dementia

From: Subjective cognitive decline and subsequent dementia: a nationwide cohort study of 579,710 people aged 66 years in South Korea

 Non-SCD groupSCD group
Total population357,654 (61.7%)222,056 (38.3%)
 Dementia events13,501 (3.8%)12,766 (5.8%)
 Person-years2,384,7451,485,548
 Incidence (events/1000 person-years)5.668.59
 Unadjusted HR (95% CI)1 [reference]1.51 (1.47–1.55)
 Sex-adjusted HR (95% CI)1 [reference]1.48 (1.44–1.51)
 aHR in model 1 (95% CI)*1 [reference]1.46 (1.43–1.50)
 aHR in model 2 (95% CI)1 [reference]1.42 (1.39–1.46)
 aHR in model 3 (95% CI)1 [reference]1.38 (1.34–1.41)
Men173,795 (48.6%)92,516 (41.7%)
 Dementia events5480 (3.2%)4399 (4.8%)
 Person-years1,147,608611,069.20
 Incidence (events/1000 person-years)4.787.20
 Unadjusted HR (95% CI)1 [reference]1.50 (1.44–1.56)
 aHR in model 1 (95% CI)*1 [reference]1.49 (1.43–1.55)
 aHR in model 2 (95% CI)1 [reference]1.44 (1.39–1.50)
 aHR in model 3 (95% CI)1 [reference]1.38 (1.32–1.44)
Women183,859 (51.4%)129,540 (58.3%)
 Dementia events8021 (4.4%)8367 (6.5%)
 Person-years1,237,137874,478.80
 Incidence (events/1000 person-years)6.489.57
 Unadjusted HR (95% CI)1 [reference]1.47 (1.42–1.51)
 aHR in model 1 (95% CI)*1 [reference]1.45 (1.40–1.49)
 aHR in model 2 (95% CI)1 [reference]1.41 (1.37–1.45)
 aHR in model 3 (95% CI)1 [reference]1.38 (1.33–1.42)
  1. aHR adjusted hazard ratio, CI confidence interval, SCD subjective cognitive decline
  2. *Adjusted for sex, income, lifestyle factors, and healthcare visit frequency (in subgroup analysis for men and women, sex was not entered as a covariate)
  3. Adjusted for sex, income, lifestyle factors, healthcare visit frequency, medical history, and medication history (in subgroup analysis for men and women, sex was not entered as a covariate)
  4. Adjusted for sex, income, lifestyle factors, healthcare visit frequency, medical history, medication history, depression screening questionnaire scores, laboratory findings, and physical examination findings (in subgroup analysis for men and women, sex was not entered as a covariate)