Fig. 3

NJK14047 treatment from 6 to 9 months of age does not affect amyloid beta precursor protein processing and degrading molecules. a Representative immunoblotting images and quantifications for proteins involved in the production of Aβ. Total protein lysates of the cortex and hippocampus were used and immunoblotted with 6E10, BACE1, and PS1 antibodies. Protein levels were quantified using ImageJ, normalized to its β-actin level. Data were shown as mean ± SEM (n = 5 per group, one-way ANOVA). b Representative immunoblotting images and quantifications for proteins involved in the elimination of Aβ. Immunoblotting was performed with IDE and NEP antibodies using total protein lysates of the cortex and hippocampus. Quantitative analysis was performed using ImageJ. The quantified protein levels were normalized to the β-actin level and expressed as mean ± SEM (n = 5 per group, one-way ANOVA)