Fig. 2
NJK14047 treatment from 6 to 9 months of age reduces Aβ plaques in the cortex and hippocampus. a, b Representative confocal microscope images of mouse brain slices stained with a thioflavin S dye and b 6E10 antibody. Thioflavin S- and 6E10-positive areas per square millimeter were quantified. For quantification, four areas in each section and four sections in each mouse were used. Data are shown as mean ± SEM (scale bar = 100 μm, n = 5 per group, one-way ANOVA). c Aβ protein level per brain cortex and hippocampus weight (mg) was measured using Aβ1–42 ELISA. Data are shown as mean ± SEM (n = 6 per group, Student’s t test). #P < 0.05 vs. wild type; *P < 0.05 vs. 5XFAD