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Fig. 4 | Alzheimer's Research & Therapy

Fig. 4

From: Reduction of NgR in perforant path decreases amyloid-β peptide production and ameliorates synaptic and cognitive deficits in APP/PS1 mice

Fig. 4

NgR reduction decreases activation of astrocytes and microglia in the hippocampus. A (a) Mouse brain sections were processed for anti-Iba1 immunohistochemistry as indicated. A (b, c) The numbers and percentage of the Iba1-positive area in the hippocampus. A (d, e) Representative bands and analysis of the Iba1 protein level. B (a, b) Representative bands of and analysis of the GFAP protein level. B (c) Mouse brain sections were processed for anti-GFAP immunohistochemistry as indicated. B (d, e) The numbers and percentage of the GFAP-positive area in the hippocampus. Data are presented as mean ± SEM. n = 5 male mice/group. The statistical analysis was performed by Student’s t test. *P < 0.05

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Alzheimer's Research & Therapy

ISSN: 1758-9193