Fig. 3
Downregulation of NgR reduces Aβ generation in APP/PS1 transgenic mice. A (a) Microdialysis experiments detected soluble Aβ in the brain. A (b, c) ISF Aβ1–42 levels were monitored in the perforant path and hippocampus. B (a) The coronal sections of the cortex were stained with an antibody against Aβ. B (b) The size of Aβ plaques was quantified and expressed as the percentage of areas occupied by Aβ plaques in the cortex. B (c) The numbers of Aβ plaques in the cortex were quantified and expressed as the amount of Aβ plaques per square millimeter. C (a–c) The size and numbers of Aβ plaques in the hippocampus were quantified. Scale bars 200 μm. Data are presented as mean ± SEM. n = 5 male mice/group. The statistical analysis was performed by Student’s t test. *P < 0.05; **P < 0.01