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Fig. 2 | Alzheimer's Research & Therapy

Fig. 2

From: Reduction of NgR in perforant path decreases amyloid-β peptide production and ameliorates synaptic and cognitive deficits in APP/PS1 mice

Fig. 2

NgR reduction improves synaptic plasticity in APP/PS1 transgenic mice. A (a) The effects of HFS on the fEPSP initial slope. A (b) Representative fEPSP traces for data shown. A (c) Cumulative data showing the mean fEPSP slope 60 min post-HFS. A (d) Cumulative data showing the mean fEPSP peak amplitude 60 min post-HFS. A (e) Cumulative data showing the PPF ratio. B (a) Analysis of the density of spines of each group of mice at 9 months of age. B (b) The density of spines in the hippocampus of each group of the mice was analyzed. Scale bars 10 μm. Data are presented as mean ± SEM. n = 4 male mice/group. The statistical analysis was performed by Student’s t test. *P < 0.05; **P < 0.01

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Alzheimer's Research & Therapy

ISSN: 1758-9193