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Table 2 Baseline clinical and cognitive characteristics of patients in parent study ALZ2002 by treatment group at start and by their Clinical Dementia Rating classification (safety analysis set)

From: Long-term safety and tolerability of atabecestat (JNJ-54861911), an oral BACE1 inhibitor, in early Alzheimer’s disease spectrum patients: a randomized, double-blind, placebo-controlled study and a two-period extension study

Baseline characteristics

Treatment group at start

Clinical and Cognitive Scales

Placebo (N = 39)

Atabecestat

10 mg (N = 37)

50 mg (N = 38)

CDR-SB†,N

39

37

38

All mean (SD)

1.5 (1.25)

1.6 (1.24)

1.6 (1.09)

Preclinical AD,N

7

8

9

Mean (SD)

0.1 (0.19)

0.4 (0.73)

0.8 (0.97)

MCI due to AD,N

32

29

29

Mean (SD)

1.8 (1.16)

1.9 (1.16)

1.8 (1.04)

CVLT-II, long-delay recall‖,N

36

36

37

All mean (SD)

11.7 (9.4)

10.3 (9.04)

12.4 (8.48)

Preclinical AD,N

7

8

9

Mean (SD)

19.7 (7.67)

15.8 (12.29)

20.7 (8.14)

MCI due to AD,N

29

28

28

Mean (SD)

9.7 (8.46)

8.8 (7.45)

9.8 (6.80)

MMSE subscale scores‡,N

39

37

38

All mean (SD)

26.3 (2.90)

24.9 (4.14)

26.2 (2.47)

Preclinical AD,N

7

8

9

Mean (SD)

29.0 (1.15)

27.8 (2.55)

27.8 (2.64)

MCI due to AD,N

32

29

29

Mean (SD)

25.8 (2.84)

24.1 (4.18)

25.7 (2.24)

RBANS—total scale score,N

39

37

38

All, mean (SD)

80.2 (17.10)

72.4 (21.99)

80.1 (17.44)

Preclinical AD,N

7

8

9

Mean (SD)

99.7 (14.68)

91.4 (23.89)

92.9 (17.49)

MCI due to AD,N

32

29

29

Mean (SD)

75.9 (14.55)

67.2 (18.66)

76.2 (15.68)

  1. †The Clinical Dementia Rating-Sum of Boxes with scores ranging from 0 to 18 with higher scores indicating more pronounced impairment
  2. ‖The California Verbal Learning Test—second edition long-delay recall subtest is derived as the sum of free recall and cued recall 20 min after the initial presentation of a word list. The lower the score, the more pronounced the impairment
  3. ‡The Mini-Mental State Examination is a questionnaire that rates participants on orientation (total score, 10), registration (total score, 3), attention, calculation (total score, 5), recall (total score, 3), and language (total score, 9). The maximum score is 30. The lower the score, the more pronounced the impairment
  4. The Repeatable Battery for the Assessment of Neuropsychological Status subsets included attention index, language index, visuospatial/constructional index, immediate memory index, and delayed memory index. The lower the score, the more pronounced the impairment
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Alzheimer's Research & Therapy

ISSN: 1758-9193