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Table 2 Baseline clinical and cognitive characteristics of patients in parent study ALZ2002 by treatment group at start and by their Clinical Dementia Rating classification (safety analysis set)

From: Long-term safety and tolerability of atabecestat (JNJ-54861911), an oral BACE1 inhibitor, in early Alzheimer’s disease spectrum patients: a randomized, double-blind, placebo-controlled study and a two-period extension study

Baseline characteristicsTreatment group at start
Clinical and Cognitive ScalesPlacebo (N = 39)Atabecestat
10 mg (N = 37)50 mg (N = 38)
CDR-SB,N393738
All mean (SD)1.5 (1.25)1.6 (1.24)1.6 (1.09)
Preclinical AD,N789
Mean (SD)0.1 (0.19)0.4 (0.73)0.8 (0.97)
MCI due to AD,N322929
Mean (SD)1.8 (1.16)1.9 (1.16)1.8 (1.04)
CVLT-II, long-delay recall,N363637
All mean (SD)11.7 (9.4)10.3 (9.04)12.4 (8.48)
Preclinical AD,N789
Mean (SD)19.7 (7.67)15.8 (12.29)20.7 (8.14)
MCI due to AD,N292828
Mean (SD)9.7 (8.46)8.8 (7.45)9.8 (6.80)
MMSE subscale scores,N393738
All mean (SD)26.3 (2.90)24.9 (4.14)26.2 (2.47)
Preclinical AD,N789
Mean (SD)29.0 (1.15)27.8 (2.55)27.8 (2.64)
MCI due to AD,N322929
Mean (SD)25.8 (2.84)24.1 (4.18)25.7 (2.24)
RBANS—total scale score,N393738
All, mean (SD)80.2 (17.10)72.4 (21.99)80.1 (17.44)
Preclinical AD,N789
Mean (SD)99.7 (14.68)91.4 (23.89)92.9 (17.49)
MCI due to AD,N322929
Mean (SD)75.9 (14.55)67.2 (18.66)76.2 (15.68)
  1. The Clinical Dementia Rating-Sum of Boxes with scores ranging from 0 to 18 with higher scores indicating more pronounced impairment
  2. The California Verbal Learning Test—second edition long-delay recall subtest is derived as the sum of free recall and cued recall 20 min after the initial presentation of a word list. The lower the score, the more pronounced the impairment
  3. The Mini-Mental State Examination is a questionnaire that rates participants on orientation (total score, 10), registration (total score, 3), attention, calculation (total score, 5), recall (total score, 3), and language (total score, 9). The maximum score is 30. The lower the score, the more pronounced the impairment
  4. The Repeatable Battery for the Assessment of Neuropsychological Status subsets included attention index, language index, visuospatial/constructional index, immediate memory index, and delayed memory index. The lower the score, the more pronounced the impairment