From: Imaging biomarkers in neurodegeneration: current and future practices
Disease | Diagnostic criteria | MRI signature |
---|---|---|
Alzheimer’s disease | McKhann et al. [110] | Disproportionate atrophy in the medial, basal and lateral temporal lobe and medial parietal cortex |
Posterior cortical atrophy | Crutch et al. [111] | Predominant occipito-parietal or occipito-temporal atrophya |
Logopenic variant PPA | Gorno-Tempini et al. [112] | Predominant left posterior perisylvian or parietal atrophy |
Behavioural variant FTD | Rascovsky et al. [113] | Frontal and/or anterior temporal atrophy |
Semantic variant PPA | Gorno-Tempini et al. [112] | Predominant anterior temporal lobe atrophy |
Non-fluent variant PPA | Gorno-Tempini et al. [112] | Predominant left posterior fronto-insular atrophy |
Dementia with Lewy bodies | McKeith et al. [114] | Relative preservation of the medial temporal lobe structuresb |
Multiple system atrophy | Gilman et al. [115] | Atrophy of the putamen, middle cerebellar peduncle, pons or cerebellum |
Progressive supranuclear palsy | Höglinger et al. [116] | Atrophy predominant in the midbrain relative to pons |