Skip to main content

Table 2 Atrophy patterns included in the current diagnostic criteria of selected neurodegenerative dementias. Only changes in T1-weighted MRI sequence are included in the MRI signature column. The MRI signatures described are supportive features for the diagnosis unless otherwise stated. PPA primary progressive aphasia. FTD frontotemporal dementia

From: Imaging biomarkers in neurodegeneration: current and future practices


Diagnostic criteria

MRI signature

Alzheimer’s disease

McKhann et al. [110]

Disproportionate atrophy in the medial, basal and lateral temporal lobe and medial parietal cortex

Posterior cortical atrophy

Crutch et al. [111]

Predominant occipito-parietal or occipito-temporal atrophya

Logopenic variant PPA

Gorno-Tempini et al. [112]

Predominant left posterior perisylvian or parietal atrophy

Behavioural variant FTD

Rascovsky et al. [113]

Frontal and/or anterior temporal atrophy

Semantic variant PPA

Gorno-Tempini et al. [112]

Predominant anterior temporal lobe atrophy

Non-fluent variant PPA

Gorno-Tempini et al. [112]

Predominant left posterior fronto-insular atrophy

Dementia with Lewy bodies

McKeith et al. [114]

Relative preservation of the medial temporal lobe structuresb

Multiple system atrophy

Gilman et al. [115]

Atrophy of the putamen, middle cerebellar peduncle, pons or cerebellum

Progressive supranuclear palsy

Höglinger et al. [116]

Atrophy predominant in the midbrain relative to pons

  1. aCore neuroimaging feature of the PCA clinico-radiological syndrome; bnon-specific biomarker for DLB, but useful to differentiate from AD