Fig. 3From: Imaging biomarkers in neurodegeneration: current and future practicesCognitively normal older adults (n = 49) underwent 3-T fMRI while performing a mnemonic discrimination task as well as PET imaging. A whole-brain multiple regression showed that increased tau burden (mean flortaucipir SUVR from Braak III/IV ROI) was related to increased task activation during object processing (covarying for age and gender). Tau-related activation increases were seen mainly in hippocampus and posterior-medial regions. Results are FDR-corrected at the cluster level (pcluster < .05, pvoxel < .001 uncorrected). The scatter plot (lower left) shows the correlation of regional Flortaucipir SUVR and object activation in posterior-medial regions. See Maass et al. [158] for study detailsBack to article page