An analysis of genetically regulated gene expression across multiple tissues implicates novel gene candidates in Alzheimer’s disease

Table 5 Biological pathways associated with Alzheimer’s disease association signals in the dorsolateral prefrontal cortex from the CMC

Pathway ID	Pathway name	Coef	SE	P
GTEx S-MultiXcan
R-HSA-8964043	Plasma lipoprotein clearance	− 0.7861	0.1745	6.64 × 10⁻⁶
CMC DLPFC
R-HSA-168179	Toll-like receptor TLR1:TLR2 cascade	0.3684	0.0263	1.32 × 10⁻⁴⁴
R-HSA-167044	Signalling to RAS	0.6713	0.0493	2.78 × 10⁻⁴²
R-HSA-187687	Signalling to ERKs	0.5786	0.0438	6.52 × 10⁻⁴⁰
R-HSA-447115	Interleukin-12 family signalling	0.6109	0.0468	7.27 × 10⁻³⁹
R-HSA-354192	Integrin alphaIIb beta3 signalling	0.6337	0.0486	8.14 × 10⁻³⁹

Coef beta coefficient from a logistic regression model testing the enrichment of genes associated with Alzheimer’s disease in Reactome pathways

ISSN: 1758-9193