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Table 5 Biological pathways associated with Alzheimer’s disease association signals in the dorsolateral prefrontal cortex from the CMC

From: An analysis of genetically regulated gene expression across multiple tissues implicates novel gene candidates in Alzheimer’s disease

Pathway IDPathway nameCoefSEP
GTEx S-MultiXcan
 R-HSA-8964043Plasma lipoprotein clearance− 0.78610.17456.64 × 10−6
CMC DLPFC
 R-HSA-168179Toll-like receptor TLR1:TLR2 cascade0.36840.02631.32 × 10−44
 R-HSA-167044Signalling to RAS0.67130.04932.78 × 10−42
 R-HSA-187687Signalling to ERKs0.57860.04386.52 × 10−40
 R-HSA-447115Interleukin-12 family signalling0.61090.04687.27 × 10−39
 R-HSA-354192Integrin alphaIIb beta3 signalling0.63370.04868.14 × 10−39
  1. Coef beta coefficient from a logistic regression model testing the enrichment of genes associated with Alzheimer’s disease in Reactome pathways