Sex-specific associations with cerebrospinal fluid biomarkers in dementia with Lewy bodies

Table 1 Baseline characteristics

	Women, n = 39	Men, n = 184	p value
Age	70.1 ± 6.0	67.7 ± 7.3	0.04
Education, years	11.0 ± 2.8	11.4 ± 2.9	0.42
Duration of complaints, years	2.3 ± 1.2	3.5 ± 2.8	< 0.001
APOE ɛ4 carrier,n(%)	22 (70%)	86 (52%)	0.08
Geriatric Depression Scale (0–15)	4 ± 3	4 ± 3	0.65
Core clinical features,n(%)
Visual hallucinations, n = 222	23 (59%)	69 (38%)	0.02
Parkinsonism, n = 216	23 (62%)	130 (73%)	0.28
RBD, n = 156	11 (55%)	99 (73%)	0.17
Cognitive fluctuations, n = 173	29 (94%)	119 (84%)	0.26
Cognitive test scores^a,n = 205
MMSE	21 ± 6	23 ± 4	0.02
RAVLT—immediate recall	− 1.94 ± 1.10	− 2.00 ± 0.95	0.74
RAVLT—delayed recall	− 1.80 ± 0.98	− 1.72 ± 0.96	0.84
VAT—12 items	− 6.20 ± 5.78	− 4.87 ± 4.99	0.31
TMT-A^b	− 5.47 ± 6.46	− 4.60 ± 4.84	0.52
TMT-B/A^b,c	− 6.93 ± 7.03	− 5.33 ± 6.42	0.32
Animal fluency	− 2.38 ± 1.02	− 1.78 ± 0.99	0.002
Biomarker status, abnormal/available,n(%)
DAT SPECT, n = 107	15/15 (100%)	79/91 (87%)	0.06
CSF Aβ42 status	30/39 (77%)	104/186 (56%)	0.02
Abnormal Tau/Aβ42 ratio (> 0.52)	21/38 (55%)	55/185 (30%)	0.002

Data represent mean ± SD, median [IQR] or n (%). Parkinsonism: bradykinesia, rigidity, or tremor
MMSE Mini Mental State Examination, RAVLT Raven auditory verbal learning test (Dutch version), VAT Visual Association Test, TMT Trail Making Test
^aAdjusted for age and education. Data of RAVLT, VAT, TMT, and animal fluency represent z scores, based on cognitively healthy subjects
^bData are inverted and log-transformed
^cMissing values are imputed based on TMT-B/A ratio for n = 101

ISSN: 1758-9193