Table 2 Cut-offs and diagnostic accuracy for the MoCA score, the MoCA z-score, and the MMSE
Group | Mild+Major NCD vs. NF | Mild NCD vs. NF |
|---|---|---|
MoCA score | ||
AUC (95% CI) | 0.94 (0.91–0.96) | 0.86 (0.81–0.91) |
Original cut-off | 25/26 | 25/26 |
Correct classification rate† | 79% | 75% |
Sensitivity (95% CI) | 94% (94–95%) | 86% (84–87%) |
Specificity (95% CI) | 63% (60–67%) | 63% (60–67%) |
Balanced cut-off | 24/25 | 24/25 |
Correct classification rate† | 82% | 74% |
Sensitivity (95% CI) | 90% (89–90%) | 74% (72–76%) |
Specificity (95% CI) | 74% (70–77%) | 74% (70–76%) |
Cut-off; Youden’s index‡ | 23/24 | 23/24 |
Cut-off; 10th percentile in NCs | 23/24 | 23/24 |
Correct classification rate† | 88% | 79% |
Sensitivity (95% CI) | 84% (83–85%) | 65% (63–67%) |
Specificity (95% CI) | 92% (90–94%) | 92% (90–94%) |
MoCAz-score* | ||
AUC (95% CI) | 0.94 (0.91–0.96) | 0.86 (0.81–0.91) |
Balanced cut-off | ≤ − 1.08 | ≤ − 0.84 |
Correct classification rate† | 86% | 76% |
Sensitivity (95% CI) | 86% (85–87%) | 76% (74–78%) |
Specificity (95% CI) | 86% (83–89%) | 76% (73–79%) |
Cut-off; Youden’s index‡ | ≤ − 1.31 | ≤ − 1.14 |
Correct classification rate† | 88% | 79% |
Sensitivity (95% CI) | 81% (80–82%) | 68% (66–70%) |
Specificity (95% CI) | 94% (92–96%) | 90% (88–92%) |
Cut-off; 10th percentile in NCs | ≤ − 1.36 | ≤ − 1.36 |
Correct classification rate† | 88% | 79% |
Sensitivity (95% CI) | 80% (79–81%) | 61% (59–63%) |
Specificity (95% CI) | 96% (95–97%) | 96% (95–97%) |
MMSE | ||
AUC (95% CI) | 0.89 (0.85–0.93) | 0.78 (0.72–0.85) |
Cut-off; Youden’s index‡ | 27/28 | 28/29 |
Correct classification rate† | 82% | 73% |
Sensitivity (95% CI) | 72% (71–73%) | 69% (67–70%) |
Specificity (95% CI) | 92% (90–94%) | 76% (72–79%) |