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Table 5 Linear regression analysis output of the association of retinal thickness at baseline with FBB global SUVR at v0 and v2

From: Association between retinal thickness and β-amyloid brain accumulation in individuals with subjective cognitive decline: Fundació ACE Healthy Brain Initiative

Retinal regionsFBB global SUVR at v0FBB global SUVR at v2
B95% CItβpB95% CItβp
Peripapillary RNFL
 Total− 0.001− 0.001–0.000− 1.87− 0.160.06− 0.001− 0.001–0.000− 1.66− 0.140.10
 Temporal0.000− 0.001–0.001− 1.28− 0.110.200.000− 0.001–0.000− 1.03− 0.090.31
 Superior0.0000.000–0.000− 0.27− 0.020.790.0000.000–0.000− 0.12− 0.120.91
 Nasal0.000− 0.001–0.000− 1.38− 0.110.170.000− 0.001–0.000− 1.42− 0.120.16
 Inferior0.0000.000–0.000− 0.31− 0.030.760.000− 0.001–0.000− 0.40− 0.030.69
ETDRS macula
 Centre0.0000.000–0.0012.370.190.02*0.0000.000–0.0012.170.180.03*
 Inner temporal0.0000.000–0.0011.860.150.070.0010.000–0.0011.950.160.05
 Inner superior0.0010.000–0.0011.760.140.080.0010.000–0.0012.180.180.03*
 Inner nasal0.0010.000–0.0012.950.230.004*0.0010.000–0.0023.270.260.001*
 Inner inferior0.0010.000–0.0012.230.180.03*0.0010.000–0.0012.550.200.01*
 Outer temporal0.0000.000–0.0010.620.050.540.000− 0.001–0.0010.370.030.71
 Outer superior0.0000.000–0.0010.540.050.590.0000.000–0.0010.820.070.41
 Outer nasal0.0000.000–0.0011.250.100.210.0010.000–0.0011.650.130.10
 Outer inferior0.0010.000–0.0012.220.180.03*0.0010.000–0.0012.250.190.03*
Macular multilayer
 GCL+0.001− 0.001–0.0031.050.090.300.001− 0.001–0.0030.860.080.39
 RNFL0.001− 0.001–0.0020.910.070.370.001− 0.001–0.0031.030.080.30
  1. A linear regression model for each of the sixteen retinal thickness measures was executed using log-transformed FBB global SUVR as the outcome, for v0 and v2 separately. In all analysis age, gender, education, APOE ε4 status and OCT retinal image quality were included as covariates
  2. *Statistical significance was set-up at p < 0.05
  3. Abbreviations: APOE apolipoprotein E, CI confidence interval, ETDRS Early Treatment Diabetic Retinopathy Study, FBB florbetaben, GCL ganglion cell layer complex, OCT optical coherence tomography, OR odds ratio, RNFL retinal nerve fiber layer, SUVR standardized uptake value ratio, v0 baseline visit, v2 follow-up visit at 2 years
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Alzheimer's Research & Therapy

ISSN: 1758-9193