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Table 3 Logistic regression model output of the association of retinal thickness measurements at baseline with PET status at v0 and v2 and clinical status change over 24 months

From: Association between retinal thickness and β-amyloid brain accumulation in individuals with subjective cognitive decline: Fundació ACE Healthy Brain Initiative

Retinal regionsPET status at v0PET status at v2Clinical status at v2
WaldOR95% CIpWaldOR95% CIpWaldOR95% CIp
Peripapillary RNFL
 Total0.690.980.94–1.030.392.760.970.94–1.010.102.381.060.98–1.140.12
 Temporal0.601.030.96–1.100.440.140.990.94–1.040.712.811.060.99–1.140.09
 Superior0.371.010.98–1.050.540.260.990.97–1.020.611.041.020.98–0.160.31
 Nasal1.190.980.95–1.020.281.930.980.95–1.000.170.031.000.96–1.050.87
 Inferior0.130.990.96–1.030.721.180.980.96–1.010.283.081.041.00–1.090.08
ETDRS macula
 Centre4.931.041.01–1.080.03*4.981.031.00–1.060.03*2.111.030.99–1.060.15
 Inner temporal4.881.061.01–1.120.03*4.821.051.01–1.090.03*1.481.030.98–1.080.23
 Inner superior3.931.051.01–1.100.047*5.541.051.00–1.090.02*1.481.030.98–1.080.22
 Inner nasal7.201.081.02–1.140.007*8.391.061.02–1.100.004*1.331.030.98–1.070.25
 Inner inferior4.141.051.00–1.100.04*5.601.051.01–1.090.02*2.341.040.99–1.090.13
 Outer temporal0.521.020.97–1.070.470.221.010.97–1.050.641.261.030.98–1.090.26
 Outer superior0.111.000.96–1.060.740.211.010.97–1.050.650.731.020.97–1.080.39
 Outer nasal2.471.040.99–1.080.121.701.020.99–1.060.192.601.040.99–1.080.11
 Outer inferior2.871.040.99–1.090.091.521.020.99–1060.223.631.051.00–1.110.06
Macular multilayer
 GCL+2.221.120.96–1.310.141.651.080.96–1.210.200.761.070.92–1.240.38
 RNFL2.351.120.97–1.300.131.051.060.95–1.190.310.321.040.91–1.200.58
  1. A 2-step logistic regression model was executed for each of the sixteen retinal thickness measures as predictors of PET status (+/−) at v0 and v2 and clinical status (SCD vs MCI) at v2, separately, and including age, gender, education, APOE ε4 status and OCT image quality as adjusting variables
  2. *Statistical significance was set-up at p < 0.05
  3. Abbreviations: APOE apolipoprotein E, CI confidence interval, ETDRS Early Treatment Diabetic Retinopathy Study, GCL ganglion cell layer, OR odds ratio, PET positron emission tomography, RNFL retinal nerve fiber layer, v0 baseline visit, v2 follow-up visit at 2 years