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Table 2 Differences in ISLT and GMLT performance between subjects who failed (N = 28) vs. passed (N = 30) the SCT at baseline, modeled by generalized estimating equation (GEE) over the baseline, 9-, 18-, and 27-month examinations

From: Disruption of cholinergic neurotransmission, within a cognitive challenge paradigm, is indicative of Aβ-related cognitive impairment in preclinical Alzheimer’s disease after a 27-month delay interval

Task

p values for comparison of linear trends across adjusted p values and four (4) time points

Method of adjustment

ISLT—Immediate Recall

0.0397*

0.0652 (binomial)

ISLT—Delayed Recall

0.0066*

0.0132* (binomial)

GMLT—Moves/Second

0.0328

0.0656 (log normal)

GMLT—Total Errors

0.0254

0.0507 (log normal)

GMLT—Delayed Recall

  

Total errors

0.2469

0.2469 (log normal)

  1. *p < 0.05
  2. ISLT International Shopping List Test, GMLT Groton Maze Learning Test