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Table 1 Demographic and clinical characteristics at baseline exam, for the full sample and for the two subgroups (those who either failed or passed the scopolamine challenge test (SCT) at their baseline exams)

From: Disruption of cholinergic neurotransmission, within a cognitive challenge paradigm, is indicative of Aβ-related cognitive impairment in preclinical Alzheimer’s disease after a 27-month delay interval

 Main outcomeFull sample (n = 58)SCT fail (n = 28)SCT pass (n = 30)  
  N (%)N (%)N (%)pCohen’s d
SexNo. of female38 (60%)20 (71%)18 (60%).296
APOENo. of ε4 carriers30 (48%)17 (58%)13 (43%).559
  Mean (SD)Mean (SD)Mean (SD)p 
AgeNo. of years63.06 (5.42)63.93 (6.31)62.44 (5.04).3490.28
EducationNo. of years17.21 (2.77)17.47 (3.46)17.14 (2.55).6890.12
SUVr (neocortex)Standardized uptake value ratio1.023 (0.19)1.10 (0.24)0.95 (0.09).0002.47
SUVr (anterior cingulate)Standardized uptake value ratio1.064 (0.22)1.197 (0.27)0.984 (0.10).0002.95
GDSTotal score1.86 (2.16)1.60 (1.45)1.94 (2.35).602− 0.16
DASS Depression SubscaleTotal Depression Subscale Score3.56 (6.70)2.60 (2.59)3.87 (7.56).526− 0.19
DASS Anxiety SubscaleTotal Anxiety Subscale Score2.73 (4.53)2.40 (3.58)2.83 (4.83).752− 0.09
DASS Stress SubscaleTotal Stress Subscale Score6.73 (6.77)6.67 (4.55)6.74 (7.38).969− 0.01
MAC-QTotal score21.80 (3.57)21.35 (3.94)21.28 (3.27).5010.15
Body mass indexBody mass index26.69 (5.50)28.66 (7.95)26.07 (4.41).1130.48
MMSETotal score29.05 (1.02)28.93 (1.16)29.08 (0.99).624− 0.15
GMLT Moves/Second (MPS)Total correct moves/second0.81 (0.20)0.78 (0.20)0.81 (0.19).573− 0.17
GMLT Total Errors (TER)Total no. of errors55.60 (14.38)53.21 (16.21)52.79 (14.80).430− 0.22
GMLT CompositeStandardized z-score− 0.02 (0.81)− 0.08 (0.89)− 0.01 (0.79).764− 0.09
ISLT Total RecallTotal words recalled (three learning trials)25.62 (4.20)24.04 (4.41)27.85 (4.16).368− 0.28
One Card Learning taskAccuracy of performance1.01 (0.10)1.05 (0.03)1.10 (0.10).085− 0.40
One Back taskAccuracy of performance1.45 (0.11)1.40 (0.14)1.46 (0.10).063− 0.54
  1. *Note: APOE apolipoprotein, SUVr standardized uptake value ratio, GDS Geriatric Depression Scale, DASS Depression, Anxiety, and Stress Scale, MAC-Q Memory Complaints Questionnaire, MMSE Mini-Mental State Examination, GMLT Groton Maze Learning Task, ISLT International Shopping List Test; bolded values are significant at the p < .001 level