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Fig. 1 | Alzheimer's Research & Therapy

Fig. 1

From: Characterization of the chromatin accessibility in an Alzheimer’s disease (AD) mouse model

Fig. 1

ATAC-seq chromatin accessibility analysis in hippocampus of Alzheimer’s disease (AD) model mice and wild type (WT) mice. a Distribution of ATAC-seq fragment size in AD and WT mice. b Density plot showing the position of THSSs in AD and WT mice. The left dashed line indicates the putative promoter region located 1 kb upstream. c Chromatin accessibility around the TSS in AD and WT mice. d Annotation of THSSs to genomic features: Exons, intergenic regions, introns, promoters, and TTS. THSSs located up to 1 kb upstream of the ATG are determined as promoter regions. e Representative distribution of chromatin-accessible regions across the genome in AD and WT mice. f The percentage of annotate peaks on promoter region in AD and WT mice. Data are shown as mean ± SD. *p < 0.05

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