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Fig. 1 | Alzheimer's Research & Therapy

Fig. 1

From: Cerebrospinal fluid phospho-tau T217 outperforms T181 as a biomarker for the differential diagnosis of Alzheimer’s disease and PET amyloid-positive patient identification

Fig. 1

CSF tau and p-tau levels in the Montpellier AD cohort. CSF concentration of total tau (E_tau) and pT181 (E_pT181) measured by ELISA (in pg/mL) in the NAD and AD population (a, b). CSF concentration of pT181 and pT217 measured by quantitative mass spectrometry (MS) (in fmol/mL) in the NAD and AD population (c, d) and in the diseases included in the cohort (e, f). , , and indicate participants with high pT181 level but normal pT217 level. The red arrow indicates participants with mixed dementia having higher MS_p217 level than controls. Differences between NAD and AD populations are statically significant (see Table 1). Abbreviations: AD Alzheimer disease, NAD non-Alzheimer disease, FTLD frontotemporal lobar degeneration, LBD Lewy body dementia, PSP progressive supranuclear palsy, ACIH adult chronic idiopathic hydrocephalus

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