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Table 2 ROC curve results—CSF biomarkers for prediction of Aβ-PET status

From: Elecsys CSF biomarker immunoassays demonstrate concordance with amyloid-PET imaging

BiomarkerAUC (95% CI)ThresholdOptimisation methodPPA (%)NPA (%)OPA (%)
Aβ420.86 (0.81–0.92)1054 pg/mLYouden818181
tTau0.81 (0.75–0.87)213 pg/mLYouden866675
pTau0.84 (0.78–0.89)21.3 pg/mLYouden817779
Aβ42/Aβ400.94 (0.89–0.98)0.064Youden909090
0.0673GMM928890
tTau/Aβ420.94 (0.90–0.98)0.258Youden839791
0.165GMM928085
pTau/Aβ420.94 (0.90–0.98)0.0183Youden909191
0.0159GMM908386
  1. Abbreviations: , β-amyloid; Aβ42, β-amyloid (1–42); Aβ42/Aβ40, β-amyloid (1–42)/β-amyloid (1–40) ratio; AUC, area under the curve; CI, confidence interval; CSF, cerebrospinal fluid; GMM, Gaussian mixture model; NPA, negative percentage agreement; OPA, overall percentage agreement; PET, positron emission tomography; PPA, positive percentage agreement; pTau, phosphorylated tau (181P); pTau/Aβ42, phosphorylated tau (181P)/β-amyloid (1–42) ratio; ROC, receiver operating characteristic; tTau, total tau; tTau/Aβ42, total tau/β-amyloid (1–42) ratio