Table 3 Biomarkers stratified by the 10-year age group
Analyte | Age group (in years) | Down syndrome | Control | p value* |
|---|---|---|---|---|
Aβ42 (pg/mL) | 0–10 | 45.3 ± 2.1 | 28.1 ± 1.6 | < 0.001 |
11–20 | 31.8 ± 2.0 | 16.2 ± 1.2 | < 0.001 | |
21–30 | 28.1 ± 2.3 | 15.7 ± 0.8 | < 0.001 | |
31–40 | 21.4 ± 1.3 | 15.0 ± 1.5 | 0.014 | |
41–50 | 22.7 ± 0.7 | 14.7 ± 0.6 | < 0.001 | |
> 50 | 22.7 ± 1.8 | 16.6 ± 0.8 | n.s. | |
NT1 tau (pg/mL) | 0–10 | 8.3 ± 0.5 | 7.9 ± 0.8 | n.s. |
11–20 | 4.3 ± 0.5 | 5.6 ± 0.5 | n.s. | |
21–30 | 4.3 ± 0.4 | 4.6 ± 0.4 | n.s. | |
31–40 | 4.2 ± 0.6 | 3.2 ± 0.6 | n.s. | |
41–50 | 4.6 ± 0.4 | 3.2 ± 0.3 | n.s. | |
> 50 | 7.0 ± 0.8 | 4.1 ± 0.2 | 0.042 | |
NfL (pg/mL) | 0–10 | 7.5 ± 0.5 | 6.3 ± 0.6 | n.s. |
11–20 | 5.1 ± 0.4 | 3.6 ± 0.3 | 0.010 | |
21–30 | 6.7 ± 0.4 | 5.4 ± 0.9 | n.s. | |
31–40 | 10.2 ± 1.6 | 6.8 ± 1.3 | n.s. | |
41–50 | 15.9 ± 1.0 | 8.3 ± 1.0 | 0.001 | |
> 50 | 31.0 ± 6.0 | 11.7 ± 1.1 | 0.023 |