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Table 3 Biomarkers stratified by the 10-year age group

From: Dynamics of plasma biomarkers in Down syndrome: the relative levels of Aβ42 decrease with age, whereas NT1 tau and NfL increase

AnalyteAge group (in years)Down syndromeControlp value*
Aβ42 (pg/mL)0–1045.3 ± 2.128.1 ± 1.6< 0.001
11–2031.8 ± 2.016.2 ± 1.2< 0.001
21–3028.1 ± 2.315.7 ± 0.8< 0.001
31–4021.4 ± 1.315.0 ± 1.50.014
41–5022.7 ± 0.714.7 ± 0.6< 0.001
> 5022.7 ± 1.816.6 ± 0.8n.s.
NT1 tau (pg/mL)0–108.3 ± 0.57.9 ± 0.8n.s.
11–204.3 ± 0.55.6 ± 0.5n.s.
21–304.3 ± 0.44.6 ± 0.4n.s.
31–404.2 ± 0.63.2 ± 0.6n.s.
41–504.6 ± 0.43.2 ± 0.3n.s.
> 507.0 ± 0.84.1 ± 0.20.042
NfL (pg/mL)0–107.5 ± 0.56.3 ± 0.6n.s.
11–205.1 ± 0.43.6 ± 0.30.010
21–306.7 ± 0.45.4 ± 0.9n.s.
31–4010.2 ± 1.66.8 ± 1.3n.s.
41–5015.9 ± 1.08.3 ± 1.00.001
> 5031.0 ± 6.011.7 ± 1.10.023
  1. Mean concentrations ± SEM
  2. *p value adjusted for multiple comparisons in age strata by Bonferroni correction