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Table 1 Biological variation of analytes

From: Dynamics of plasma biomarkers in Down syndrome: the relative levels of Aβ42 decrease with age, whereas NT1 tau and NfL increase

AssayDaytimeMean ± SD (range) level for all 10 donors (pg/mL)Mean ± SD (range) intra-subject %CV for all 10 donors
Aβ42Morning20.07 ± 2.81 (16.1–26.2)3.8 ± 1.9% (0.9–6.2%)
Evening20.47 ± 2.89 (16.3–25.1)5.1 ± 3.4% (1.0–12.2%)
NT1 tauMorning2.31 ± 0.49 (1.4–3.4)9.3 ± 5.3% (1.3–20.3%)
Evening2.26 ± 0.51 (1.5–3.5)8.7 ± 7.3% (1.1–26.5%)
NfLMorning7.20 ± 3.30 (2.4–13.4)7.3 ± 4.7% (0.4–15.0%)
Evening7.09 ± 3.03 (2.5–13.7)8.9 ± 4.3% (3.3–17.1%)
  1. Abbreviations: SD standard deviation, %CV percentage coefficient of variation