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Fig. 3 | Alzheimer's Research & Therapy

Fig. 3

From: Dynamics of plasma biomarkers in Down syndrome: the relative levels of Aβ42 decrease with age, whereas NT1 tau and NfL increase

Fig. 3

Relative levels of plasma Aβ42 decrease in DS with age, whereas the relative levels of NT1 tau and NfL tend to increase. To compare relative changes of plasma biomarkers in DS compared to controls, we calculated the difference between each sex- and age-matched pair (Δ = DS − control). For a ΔAβ42, b ΔNT1 tau, and c ΔNfL, each point represents a single difference value. df Difference values are also grouped in 10 year intervals. Each open circle represents a single individual. Mean and standard error of the group mean are shown. a, d Aβ42 decreases with age in DS. b, e NT1 tau is highly variable in the first 3 decades of life, but tends to increase in later life in DS. c, f ΔNfL is relatively constant in the first 30 years of life, but increases in DS with age. Differences were assessed with one sample t test (normally distributed data) or one sample Wilcoxon signed-rank test (non-normally distributed data). p values were adjusted for multiple testing using Bonferroni correction. *p < 0.05; **p < 0.01; ***p < 0.001

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