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Table 1 Demographics

From: The age-related effect on cognitive performance in cognitively healthy elderly is mainly caused by underlying AD pathology or cerebrovascular lesions: implications for cutoffs regarding cognitive impairment

 

A. Study cohort

B. No progress in CDR

C. No amyloid or tau pathology

D. No vascular pathology

E. No measurable in vivo pathology

Participants, N

297

278

223

161

120

MMSE score, mean (SD)a

29.1 (0.9)

29.1 (0.9)

29.1 (0.9)

29.1 (0.9)

29.1 (0.9)

Age, mean (SD)

73.5 (5.0)

73.4 (5.0)

73.4 (5.0)

72.5 (4.6)

72.2 (4.6)

Education years, mean (SD)

12.3 (3.7)

12.3 (3.8)

12.2 (3.6)

12.5 (0.9)

12.6 (3.5)

Gender

 Male

39.4%

38.8%

39.5%

41.6%

42.5%

 Female

60.6%

61.2%

60.5%

58.4%

57.5%

APOE ε4 (≥ 1 allele)

27.3%

25.9%

16.3%

30.8%

20.3%

Prevalence of abnormal biomarkers

 CSF Aβ42/40 < 0.059

24.9%

23.0%

0%

24.2%

0%

 CSF P-tau > 28 pg/mL

15.2%

13.3%

0%

14.3%

0%

 Log CSF NfL > 3.33 pg/mL

2.4%

1.8%

2.2%

1.2%

0%

 White matter lesionsb

45.5%

43.9%

44.8%

0%

0%

≥ 1 Cortical infarctions

1.3%

1.1%

1.7%

0%

0%

Comorbidity

 Hypertension

43.4%

42.8%

43.5%

41.0%

43.3%

 Diabetes

10.1%

10.4%

9.4%

11.2%

10.0%

 Ischemic heart disease

6.7%

6.8%

6.3%

4.3%

2.5%

  1. aAll groups have a high MMSE score due to the inclusion criteria of MMSE ≥ 28 points. bMeasured as Fazekas score ≥ 2 point in any region