Skip to main content

Table 1 Demographics

From: The age-related effect on cognitive performance in cognitively healthy elderly is mainly caused by underlying AD pathology or cerebrovascular lesions: implications for cutoffs regarding cognitive impairment

 A. Study cohortB. No progress in CDRC. No amyloid or tau pathologyD. No vascular pathologyE. No measurable in vivo pathology
Participants, N297278223161120
MMSE score, mean (SD)a29.1 (0.9)29.1 (0.9)29.1 (0.9)29.1 (0.9)29.1 (0.9)
Age, mean (SD)73.5 (5.0)73.4 (5.0)73.4 (5.0)72.5 (4.6)72.2 (4.6)
Education years, mean (SD)12.3 (3.7)12.3 (3.8)12.2 (3.6)12.5 (0.9)12.6 (3.5)
Gender
 Male39.4%38.8%39.5%41.6%42.5%
 Female60.6%61.2%60.5%58.4%57.5%
APOE ε4 (≥ 1 allele)27.3%25.9%16.3%30.8%20.3%
Prevalence of abnormal biomarkers
 CSF Aβ42/40 < 0.05924.9%23.0%0%24.2%0%
 CSF P-tau > 28 pg/mL15.2%13.3%0%14.3%0%
 Log CSF NfL > 3.33 pg/mL2.4%1.8%2.2%1.2%0%
 White matter lesionsb45.5%43.9%44.8%0%0%
≥ 1 Cortical infarctions1.3%1.1%1.7%0%0%
Comorbidity
 Hypertension43.4%42.8%43.5%41.0%43.3%
 Diabetes10.1%10.4%9.4%11.2%10.0%
 Ischemic heart disease6.7%6.8%6.3%4.3%2.5%
  1. aAll groups have a high MMSE score due to the inclusion criteria of MMSE ≥ 28 points. bMeasured as Fazekas score ≥ 2 point in any region