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Fig. 2 | Alzheimer's Research & Therapy

Fig. 2

From: Functional neuroimaging in subjective cognitive decline: current status and a research path forward

Fig. 2

Proposed functional model of subjective cognitive decline. a Incipient neurodegeneration and synapse loss lead to disruption in short- and long-range functional connections within and between default mode, executive control, and salience networks. This disconnectivity may in turn lead to information loss and noisy signal propagation that directly disrupts memory and executive functions, and indirectly disrupts those functions though reduced ability of the salience network to modulate the activity of the default mode and executive control networks with control signals. Disrupted memory and executive functioning in turn results in the personal experience of deteriorating cognitive ability. b Default mode (red), executive control (blue), and salience (green) networks visualized with Neurosynth uniformity test images [110]. Search terms included “default network,” “executive network,” and “salience network.” Z-score thresholds set at 6

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